Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7458.098 | 0.4680 | -0.4683 | 0.5731 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7463.098 | 0.9735 | 0.8927 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7463.098 | 0.9478 | 0.7920 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7463.098 | 1.0245 | 1.1016 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7463.098 | 0.9597 | 0.8381 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7463.098 | 0.9570 | 0.8279 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7463.098 | 1.0145 | 1.0600 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7463.098 | 0.9587 | 0.8344 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7463.098 | 0.9083 | 0.6423 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7463.098 | 0.9709 | 0.8827 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7464.098 | 0.9932 | 0.9786 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7464.098 | 0.9637 | 0.8862 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7464.098 | 1.0116 | 1.0370 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7464.098 | 1.0228 | 1.0727 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7464.098 | 0.9741 | 0.9184 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7464.098 | 0.9815 | 0.9416 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7464.098 | 0.9007 | 0.6942 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7464.098 | 0.9749 | 0.9208 | 0.6305 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7464.098 | 0.9813 | 0.9409 | 0.6305 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7465.098 | 0.9980 | 0.9967 | 1.2188 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7465.098 | 0.8474 | 0.7459 | 1.2188 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7465.098 | 0.9081 | 0.8479 | 1.2188 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7465.098 | 0.9634 | 0.9397 | 1.2188 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7465.098 | 0.9733 | 0.9560 | 1.2188 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7465.098 | 0.8994 | 0.8334 | 1.2188 |