Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5904.098 | 0.9224 | 0.8819 | 1.3264 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5906.098 | 1.0108 | 1.0270 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5906.098 | 0.9779 | 0.9451 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5906.098 | 1.0127 | 1.0316 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5906.098 | 0.9967 | 0.9919 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5906.098 | 0.9877 | 0.9695 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5906.098 | 0.9445 | 0.8631 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5906.098 | 0.6411 | 0.1513 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5906.098 | 0.3050 | -0.5424 | 0.8050 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5906.098 | 0.2759 | -0.5961 | 0.8050 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5908.098 | 0.9399 | 0.8064 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5908.098 | 0.8980 | 0.6763 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5908.098 | 0.9647 | 0.8855 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5908.098 | 0.9444 | 0.8206 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5908.098 | 0.9091 | 0.7104 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5908.098 | 0.9462 | 0.8265 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5908.098 | 0.9105 | 0.7147 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5908.098 | 0.9557 | 0.8567 | 0.6091 | |
| BT-483 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5908.098 | 0.9224 | 0.7516 | 0.6091 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5909.098 | 1.0905 | 1.0671 | 2.6253 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5909.098 | 1.0785 | 1.0584 | 2.6253 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5909.098 | 0.9989 | 0.9991 | 2.6253 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5909.098 | 1.0180 | 1.0136 | 2.6253 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5909.098 | 1.0239 | 1.0181 | 2.6253 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5909.098 | 0.9181 | 0.9360 | 2.6253 |