Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 133 | uM | 10753.144 | 0.0584 | -0.7748 | 1.3008 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.000512 | uM | 12000.168 | 0.9931 | 0.9826 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.00256 | uM | 12000.168 | 0.9212 | 0.8021 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.0128 | uM | 12000.168 | 1.0048 | 1.0121 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.064 | uM | 12000.168 | 0.9432 | 0.8569 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.32 | uM | 12000.168 | 0.9216 | 0.8030 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 1.6 | uM | 12000.168 | 0.8966 | 0.7410 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 8 | uM | 12000.168 | 0.2590 | -0.6403 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 40 | uM | 12000.168 | 0.2614 | -0.6361 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 200 | uM | 12000.168 | 0.3245 | -0.5211 | 0.7873 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.000341 | uM | 12084.144 | 0.9954 | 0.9937 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.00171 | uM | 12084.144 | 0.9027 | 0.8655 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.00853 | uM | 12084.144 | 1.0343 | 1.0464 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.0427 | uM | 12084.144 | 0.9304 | 0.9042 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 0.213 | uM | 12084.144 | 0.9565 | 0.9404 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 1.07 | uM | 12084.144 | 0.9304 | 0.9042 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 5.33 | uM | 12084.144 | 0.3042 | -0.1100 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 26.7 | uM | 12084.144 | 0.6380 | 0.4732 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 133 | uM | 12084.144 | 0.3733 | 0.0230 | 1.4700 | |
| HCC1419 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 0.000512 | uM | 12001.168 | 1.0146 | 1.0594 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 0.00256 | uM | 12001.168 | 0.9946 | 0.9782 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 0.0128 | uM | 12001.168 | 1.0976 | 1.4153 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 0.064 | uM | 12001.168 | 0.9935 | 0.9735 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 0.32 | uM | 12001.168 | 0.9498 | 0.8017 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 1.6 | uM | 12001.168 | 1.0356 | 1.1470 | 0.4934 |