Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Ispinesib | KSP | Kinesin | 33.3 | uM | 7546.067 | 0.0061 | -0.9950 | 0.8509 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7552.067 | 1.0523 | 1.1022 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7552.067 | 1.0321 | 1.0628 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7552.067 | 1.0287 | 1.0561 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7552.067 | 0.9947 | 0.9896 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7552.067 | 0.5838 | 0.1814 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7552.067 | 0.5339 | 0.0825 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7552.067 | 0.6188 | 0.2507 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7552.067 | 0.5351 | 0.0849 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7552.067 | 0.0087 | -0.9808 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7553.067 | 1.0309 | 1.0545 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7553.067 | 1.0174 | 1.0307 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7553.067 | 0.9731 | 0.9524 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7553.067 | 1.0057 | 1.0101 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7553.067 | 0.5922 | 0.2580 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7553.067 | 0.5011 | 0.0852 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7553.067 | 0.5410 | 0.1613 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7553.067 | 0.5187 | 0.1190 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7553.067 | 0.0080 | -0.9722 | 1.1302 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7555.067 | 0.9808 | 0.9771 | 1.6890 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7555.067 | 1.0104 | 1.0123 | 1.6890 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7555.067 | 0.9763 | 0.9718 | 1.6890 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7555.067 | 0.9750 | 0.9702 | 1.6890 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7555.067 | 0.5671 | 0.4295 | 1.6890 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7555.067 | 0.4780 | 0.2919 | 1.6890 |