Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7451.067 | 0.9852 | 0.9856 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7451.067 | 0.2546 | 0.0284 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7451.067 | 0.2417 | 0.0027 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7451.067 | 0.2387 | -0.0032 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7451.067 | 0.1568 | -0.1875 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7451.067 | 0.0089 | -0.7986 | 2.0570 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7452.067 | 1.0312 | 1.0363 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7452.067 | 1.0002 | 1.0002 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7452.067 | 0.9948 | 0.9939 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7452.067 | 0.9546 | 0.9464 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7452.067 | 0.6444 | 0.5471 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7452.067 | 0.5933 | 0.4741 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7452.067 | 0.5552 | 0.4180 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7452.067 | 0.1532 | -0.3318 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7452.067 | 0.0045 | -0.9148 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7453.067 | 1.0647 | 1.0849 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7453.067 | 1.0625 | 1.0820 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7453.067 | 1.1079 | 1.1406 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7453.067 | 1.0751 | 1.0984 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7453.067 | 0.7538 | 0.6581 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7453.067 | 0.6365 | 0.4822 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7453.067 | 0.5907 | 0.4106 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7453.067 | 0.1887 | -0.3382 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7453.067 | 0.0045 | -0.9441 | 1.5080 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7456.067 | 0.9861 | 0.9851 | 1.8797 |