Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10520.139 | 0.2153 | 0.3130 | 3.6491 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 11057.151 | 0.9438 | 0.9725 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 11057.151 | 0.9386 | 0.9698 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 11057.151 | 1.0523 | 1.0246 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 11057.151 | 0.9421 | 0.9716 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 11057.151 | 0.8760 | 0.9375 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.267 | uM | 11057.151 | 0.6102 | 0.7766 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 1.33 | uM | 11057.151 | 0.3115 | 0.5119 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 6.67 | uM | 11057.151 | 0.2319 | 0.4087 | 4.1698 | |
| SUM159PT | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 33.3 | uM | 11057.151 | 0.2225 | 0.3947 | 4.1698 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12269.157 | 0.9477 | 0.8106 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12269.157 | 1.3214 | 2.3518 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12269.157 | 1.2917 | 2.2136 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12269.157 | 0.9762 | 0.9126 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12269.157 | 1.3711 | 2.5890 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12269.157 | 0.9516 | 0.8244 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12269.157 | 0.8003 | 0.3235 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12269.157 | 1.0989 | 1.3818 | 0.5397 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12269.157 | 1.1431 | 1.5625 | 0.5397 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10579.139 | 0.8940 | 0.8106 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10579.139 | 0.9127 | 0.8442 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10579.139 | 1.0014 | 1.0026 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10579.139 | 0.9556 | 0.9209 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10579.139 | 0.9883 | 0.9792 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10579.139 | 0.9742 | 0.9542 | 1.1260 |