Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10694.151 | 1.0551 | 1.0445 | 2.4341 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10694.151 | 1.0002 | 1.0001 | 2.4341 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10694.151 | 0.8771 | 0.8951 | 2.4341 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10694.151 | 0.6554 | 0.6813 | 2.4341 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10694.151 | 0.5201 | 0.5289 | 2.4341 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10694.151 | 0.6319 | 0.6563 | 2.4341 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10816.151 | 1.1287 | 1.2667 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10816.151 | 1.1525 | 1.3160 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10816.151 | 1.0675 | 1.1396 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10816.151 | 1.0637 | 1.1319 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10816.151 | 1.0885 | 1.1833 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10816.151 | 0.9747 | 0.9478 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10816.151 | 0.8069 | 0.6020 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10816.151 | 0.8595 | 0.7102 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10816.151 | 0.8249 | 0.6390 | 0.9672 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12319.157 | 0.9854 | 0.9710 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12319.157 | 0.8872 | 0.7756 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12319.157 | 1.0291 | 1.0578 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12319.157 | 0.7924 | 0.5868 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12319.157 | 0.8453 | 0.6922 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12319.157 | 0.9240 | 0.8488 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12319.157 | 0.6626 | 0.3283 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12319.157 | 0.5968 | 0.1972 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12319.157 | 0.6034 | 0.2103 | 1.0058 | |
| MB 157 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 12580.171 | 1.0469 | 1.0457 | 2.0272 |