Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9566.001 | 0.7528 | 0.7485 | 2.1122 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9566.001 | 0.6388 | 0.6176 | 2.1122 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9566.001 | 0.6820 | 0.6685 | 2.1122 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9566.001 | 0.7219 | 0.7141 | 2.1122 | |
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9566.001 | 0.2593 | 0.0556 | 2.1122 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10061.001 | 0.9969 | 0.9964 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10061.001 | 1.0494 | 1.0562 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10061.001 | 1.0805 | 1.0910 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10061.001 | 0.9692 | 0.9644 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10061.001 | 0.6658 | 0.5832 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10061.001 | 0.6384 | 0.5455 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10061.001 | 0.6785 | 0.6005 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10061.001 | 0.6132 | 0.5101 | 1.7406 | |
| MCF12A | NM | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10061.001 | 0.0236 | -0.7674 | 1.7406 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7874.001 | 0.9469 | 0.9284 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7874.001 | 0.9800 | 0.9732 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7874.001 | 1.0395 | 1.0524 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7874.001 | 0.9369 | 0.9148 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7874.001 | 0.7957 | 0.7168 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7874.001 | 0.6151 | 0.4455 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7874.001 | 0.6629 | 0.5196 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7874.001 | 0.5553 | 0.3500 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7874.001 | 0.4382 | 0.1523 | 1.4967 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7875.001 | 1.1208 | 1.1624 | 1.4600 | |
| MCF7 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7875.001 | 1.0069 | 1.0095 | 1.4600 |