Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0924 | uM | 10264.131 | 0.6716 | 0.5211 | 1.4548 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.462 | uM | 10264.131 | 0.6926 | 0.5537 | 1.4548 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 2.31 | uM | 10264.131 | 0.6690 | 0.5171 | 1.4548 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 11.6 | uM | 10264.131 | 0.6957 | 0.5585 | 1.4548 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 57.8 | uM | 10264.131 | 0.6599 | 0.5029 | 1.4548 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 289 | uM | 10264.131 | 0.6997 | 0.5647 | 1.4548 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1440 | uM | 10264.131 | 0.6465 | 0.4818 | 1.4548 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7220 | uM | 10264.131 | 0.5058 | 0.2519 | 1.4548 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7867.011 | 0.9678 | 0.9726 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7867.011 | 0.9908 | 0.9922 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7867.011 | 0.7089 | 0.7295 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7867.011 | 0.3383 | 0.2655 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7867.011 | 0.3429 | 0.2728 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7867.011 | 0.2752 | 0.1599 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7867.011 | 0.1744 | -0.0433 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7867.011 | 0.1455 | -0.1138 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7867.011 | 0.1419 | -0.1230 | 2.3684 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7870.011 | 0.9982 | 0.9983 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7870.011 | 0.9474 | 0.9498 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7870.011 | 0.6977 | 0.6886 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7870.011 | 0.4029 | 0.3043 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7870.011 | 0.4023 | 0.3035 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7870.011 | 0.2883 | 0.1144 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7870.011 | 0.1879 | -0.0887 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7870.011 | 0.1438 | -0.1964 | 2.1270 |