Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7793.011 | 0.1596 | -0.5971 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7793.011 | 0.1724 | -0.5689 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7793.011 | 0.1287 | -0.6660 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7793.011 | 0.1116 | -0.7052 | 1.1456 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.000168 | uM | 9146.12 | 0.8607 | 0.7480 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00084 | uM | 9146.12 | 1.0012 | 1.0022 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0042 | uM | 9146.12 | 0.9893 | 0.9807 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.021 | uM | 9146.12 | 0.3086 | -0.3042 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.105 | uM | 9146.12 | 0.1217 | -0.6984 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.525 | uM | 9146.12 | 0.1391 | -0.6599 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 2.62 | uM | 9146.12 | 0.1667 | -0.5997 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 13.1 | uM | 9146.12 | 0.1389 | -0.6602 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 65.6 | uM | 9146.12 | 0.1222 | -0.6973 | 1.1135 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.000168 | uM | 9158.12 | 0.9837 | 0.9548 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00084 | uM | 9158.12 | 1.1476 | 1.4229 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0042 | uM | 9158.12 | 1.1112 | 1.3166 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.021 | uM | 9158.12 | 1.0512 | 1.1441 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.105 | uM | 9158.12 | 0.9696 | 0.9157 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.525 | uM | 9158.12 | 1.0514 | 1.1447 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 2.62 | uM | 9158.12 | 0.9479 | 0.8563 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 13.1 | uM | 9158.12 | 0.8604 | 0.6220 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 65.6 | uM | 9158.12 | 0.9688 | 0.9135 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9163.011 | 1.0268 | 1.0861 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9163.011 | 1.0347 | 1.1118 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9163.011 | 1.0296 | 1.0952 | 0.6266 |