Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 11936.154 | 0.9127 | 0.7906 | 0.8259 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 10872.154 | 0.9962 | 0.9946 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.000427 | uM | 10872.154 | 1.0680 | 1.0964 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.00213 | uM | 10872.154 | 1.0390 | 1.0556 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 10872.154 | 1.0364 | 1.0518 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 10872.154 | 1.0525 | 1.0745 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.267 | uM | 10872.154 | 1.0242 | 1.0345 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 1.33 | uM | 10872.154 | 1.0533 | 1.0758 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 10872.154 | 1.0028 | 1.0039 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 10872.154 | 1.1094 | 1.1542 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.000171 | uM | 12523.167 | 1.0036 | 1.0069 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.000853 | uM | 12523.167 | 0.9459 | 0.8958 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.00427 | uM | 12523.167 | 0.9955 | 0.9914 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0213 | uM | 12523.167 | 0.9735 | 0.9489 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.107 | uM | 12523.167 | 0.9773 | 0.9564 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.533 | uM | 12523.167 | 0.9726 | 0.9472 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 2.67 | uM | 12523.167 | 0.9544 | 0.9122 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 13.3 | uM | 12523.167 | 0.9905 | 0.9816 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 66.7 | uM | 12523.167 | 0.9582 | 0.9196 | 1.0398 | |
| HCC1806 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 12239.154 | 0.9894 | 0.9903 | 2.2015 | |
| HCC1806 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.000427 | uM | 12239.154 | 0.9607 | 0.9639 | 2.2015 | |
| HCC1806 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.00213 | uM | 12239.154 | 0.9866 | 0.9878 | 2.2015 | |
| HCC1806 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 12239.154 | 0.9912 | 0.9920 | 2.2015 | |
| HCC1806 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 12239.154 | 0.9474 | 0.9515 | 2.2015 | |
| HCC1806 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.267 | uM | 12239.154 | 0.9740 | 0.9762 | 2.2015 |