Highly-multiplexed imaging by Cyclic Immunofluorescence (CycIF) of protein levels and protein phosphorylation states in the MCF 10A breast cell line treated with EGF or four kinase inhibitors - Dataset (ID:20267)
- Detail
- Small Molecules Studied
- Cell Lines Studied
- Proteins Studied
- Antibodies Studied
- Other Reagents Studied
- Results
Proteins Studied
Download: Excel (XLSX), Comma-separated (CSV)
| LINCS ID | Name | HMS LINCS ID | UniProt ID | Alternative Names | Provider | Mutation | Phosphlorylation State | Domain | Protein Description |
|---|---|---|---|---|---|---|---|---|---|
| 200482 | Akt-1 | 200482 | P31749 | RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha | |||||
| 200483 | Akt-2 | 200483 | P31751 | RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta | |||||
| 200484 | Akt-3 | 200484 | Q9Y243 | RAC-gamma serine/threonine-protein kinase; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2 | |||||
| 200507 | EGFR | 200507 | P00533 | Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 | |||||
| 200537 | mTOR | 200537 | P42345 | Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1 | |||||
| 200543 | p53 | 200543 | P04637 | Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 | |||||
| 200598 | VEGFR-2 | 200598 | P35968 | Vascular endothelial growth factor receptor 2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD309; VEGFR2 | |||||
| 201294 | H3 (pS10) | 201294 | P68431 | pS10 | |||||
| 201295 | p21 | 201295 | P38936 | Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6 | |||||
| 201296 | KI-67 | 201296 | P46013 | Antigen KI-67 | |||||
| 201297 | Rb (pS807; pS811) | 201297 | P06400 | pS807; pS811 | |||||
| 201298 | S6 (pS235; pS236) | 201298 | P62753 | pS235; pS236 | |||||
| 201299 | S6 (pS240; pS244) | 201299 | P62753 | pS240; pS244 | |||||
| 201302 | PCNA | 201302 | P12004 | Proliferating cell nuclear antigen; Cyclin | |||||
| 201303 | ERK-1 (pT202; pY204) | 201303 | P27361 | pT202; pY204 | |||||
| 201304 | ERK-2 (pT185; pY187) | 201304 | P28482 | pT185; pY187 | |||||
| 201305 | K4 | 201305 | P19013 | Keratin, type II cytoskeletal 4; Cytokeratin-4; CK-4; Keratin-4; Type-II keratin Kb4 | |||||
| 201306 | K5 | 201306 | P13647 | Keratin, type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; Type-II keratin Kb5 | |||||
| 201307 | K6A | 201307 | P02538 | Keratin, type II cytoskeletal 6A; Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; Type-II keratin Kb6; Hom s 5 | |||||
| 201308 | K6B | 201308 | P04259 | Keratin, type II cytoskeletal 6B; Cytokeratin-6B; CK-6B; Keratin-6B; Type-II keratin Kb10 | |||||
| 201309 | K6C | 201309 | P48668 | Keratin, type II cytoskeletal 6C; Cytokeratin-6C; CK-6C; Cytokeratin-6E; CK-6E; Keratin K6h; Keratin-6C; Type-II keratin Kb12 | |||||
| 201310 | K8 | 201310 | P05787 | Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Type-II keratin Kb8 | |||||
| 201311 | K10 | 201311 | P13645 | Keratin, type I cytoskeletal 10; Cytokeratin-10; CK-10 | |||||
| 201312 | K13 | 201312 | P13646 | Keratin, type I cytoskeletal 13; Cytokeratin-13; CK-13 | |||||
| 201313 | K18 | 201313 | P05783 | Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18 |