Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Lapatinib | 10 | 625.00 | 10.4833 | 10.4831 | 0.5582 | 0.0001 | 5.0000 | 1.0175 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9058 | 9.0342 | 11.2515 | 0.2868 | -0.9982 | 5.0000 | 0.0005 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9607 |
| MCF7 | Lapatinib | 10 | 1250.00 | 9.5141 | 7.3956 | 0.4749 | 0.3045 | 3.7284 | 0.9769 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9588 | 7.789 | 7.6883 | 0.2963 | 0.0229 | 3.5950 | 0.0390 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9733 |
| MCF7 | Lapatinib | 10 | 2500.00 | 8.3531 | 4.0463 | 0.4922 | 0.4867 | 5.0000 | 0.9606 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.961 | 5.4143 | 4.1756 | 0.3715 | 0.3635 | 4.9987 | 0.0498 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9724 |
| MCF7 | Lapatinib | 10 | 5000.00 | 9.3172 | 5.2446 | 0.4842 | 0.3891 | 2.6200 | 0.9651 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9836 | 6.9653 | 5.6941 | 0.3535 | 0.2036 | 2.5955 | 0.0448 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9884 |
| MCF7 | Palbociclib | 10 | 156.25 | 1.1512 | 0.692 | 0.4454 | 0.4608 | 5.0000 | 0.8019 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9642 | 0.8853 | 0.6797 | 0.3734 | 0.3666 | 5.0000 | 0.2329 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.951 |
| MCF7 | Palbociclib | 10 | 312.50 | 0.8181 | 0.2923 | 0.3916 | 0.4029 | 1.5925 | 0.7035 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9631 | 0.5429 | 0.3287 | 0.3361 | 0.3599 | 2.5341 | 0.3076 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9828 |
| MCF7 | Palbociclib | 10 | 625.00 | 0.8884 | 0.3347 | 0.3508 | 0.3536 | 1.2577 | 0.7015 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9798 | 0.823 | 0.4431 | 0.2996 | 0.3244 | 1.6899 | 0.2882 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9814 |
| MCF7 | Palbociclib | 10 | 1250.00 | 0.6482 | 0.3226 | 0.3793 | 0.3994 | 2.2973 | 0.7091 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9903 | 0.6413 | 0.3634 | 0.3641 | 0.3950 | 2.7483 | 0.2827 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9909 |
| MCF7 | Palbociclib | 10 | 2500.00 | 1.7746 | 0.1799 | 0.4565 | 0.4283 | 0.8487 | 0.6856 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9722 | 1.2586 | 0.2168 | 0.4297 | 0.4040 | 0.9382 | 0.3170 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9766 |
| MCF7 | Palbociclib | 10 | 5000.00 | inf | 0.119 | 0.5698 | 0.5495 | 0.8030 | 0.7329 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9777 | 1.6327 | 0.1344 | 0.4583 | 0.4317 | 0.7969 | 0.3304 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9743 |
| MCF7 | Erlotinib | 10 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| MCF7 | Erlotinib | 10 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| MCF7 | Erlotinib | 10 | 625.00 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0500 | flat fit: x = Einf | -inf | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| MCF7 | Erlotinib | 10 | 1250.00 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0494 | flat fit: x = Einf | -1058.7016 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0497 | flat fit: x = Einf | -6242.1833 |
| MCF7 | Erlotinib | 10 | 2500.00 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0414 | flat fit: x = Einf | -5.217 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0413 | flat fit: x = Einf | -5.064 |
| MCF7 | Erlotinib | 10 | 5000.00 | inf | inf | 0.9493 | 0.9493 | 0.0000 | 1.0272 | flat fit: x = Einf | -0.2401 | inf | inf | 0.9450 | 0.9450 | 0.0000 | -0.0277 | flat fit: x = Einf | -0.1701 |
| MCF7 | Nilotinib | 10 | 156.25 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0449 | flat fit: x = Einf | -14.2993 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | flat fit: x = Einf | -inf |
| MCF7 | Nilotinib | 10 | 312.50 | inf | inf | 1.0500 | 1.0500 | 0.0000 | 1.0448 | flat fit: x = Einf | -2.4981 | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0423 | flat fit: x = Einf | -0.9184 |
| MCF7 | Nilotinib | 10 | 625.00 | inf | inf | 0.5262 | 0.5262 | 0.0000 | 0.9825 | flat fit: x = Einf | 0.3603 | inf | inf | 0.5507 | 0.5507 | 0.0000 | 0.0166 | flat fit: x = Einf | 0.3516 |
| MCF7 | Nilotinib | 10 | 1250.00 | inf | 5.3818 | 0.4669 | 0.5184 | 4.9987 | 0.9626 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9403 | inf | 5.386 | 0.4812 | 0.5472 | 4.9989 | 0.0332 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9223 |
| MCF7 | Nilotinib | 10 | 2500.00 | 6.6038 | 4.8647 | 0.3557 | 0.3915 | 5.0000 | 0.9142 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9861 | 6.2994 | 5.0209 | 0.2830 | 0.3392 | 5.0000 | 0.0907 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9781 |
| MCF7 | Nilotinib | 10 | 5000.00 | 7.0822 | 4.6275 | 0.4251 | 0.4405 | 5.0000 | 0.8998 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9827 | 5.8021 | 5.0783 | 0.2169 | 0.2432 | 5.0000 | 0.1167 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9848 |
| MCF7 | Taxol | 10 | 156.25 | 0.0118 | 0.0039 | 0.3434 | 0.4012 | 1.4706 | 0.6332 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9378 | 0.0102 | 0.0055 | 0.1794 | 0.2689 | 1.2484 | 0.4248 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9224 |
| MCF7 | Taxol | 10 | 312.50 | 0.0025 | 0.0016 | 0.3791 | 0.3816 | 3.2485 | 0.5510 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9875 | 0.0024 | 0.0018 | 0.3165 | 0.3167 | 3.1935 | 0.4903 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9849 |
| MCF7 | Taxol | 10 | 625.00 | 0.0032 | 0.002 | 0.2831 | 0.3189 | 2.1212 | 0.5205 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9776 | 0.0038 | 0.0026 | 0.1822 | 0.2290 | 1.6034 | 0.5215 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9674 |