LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | PIK-93 | 10 | uM | LJP5 | 72 | hr | 1401 | 1491 | 4245 | 0.3532 | 0.0410 |
| SK-BR-3 | Dactolisib | 0.04 | uM | LJP5 | 72 | hr | 1401 | 1558 | 4245 | 0.3679 | 0.0681 |
| SK-BR-3 | Dactolisib | 0.12 | uM | LJP5 | 72 | hr | 1401 | 1559 | 4245 | 0.3671 | 0.0664 |
| SK-BR-3 | Dactolisib | 0.37 | uM | LJP5 | 72 | hr | 1401 | 1347 | 4245 | 0.3173 | -0.0265 |
| SK-BR-3 | Dactolisib | 1.11 | uM | LJP5 | 72 | hr | 1401 | 1349 | 4245 | 0.3187 | -0.0237 |
| SK-BR-3 | Dactolisib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 1560 | 4245 | 0.3692 | 0.0707 |
| SK-BR-3 | Dactolisib | 10 | uM | LJP5 | 72 | hr | 1401 | 1687 | 4245 | 0.4001 | 0.1257 |
| SK-BR-3 | Alpelisib | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4129 | 4245 | 0.9731 | 0.9667 |
| SK-BR-3 | Alpelisib | 0.12 | uM | LJP5 | 72 | hr | 1401 | 3833 | 4245 | 0.9031 | 0.8763 |
| SK-BR-3 | Alpelisib | 0.37 | uM | LJP5 | 72 | hr | 1401 | 3342 | 4245 | 0.7886 | 0.7238 |
| SK-BR-3 | Alpelisib | 1.11 | uM | LJP5 | 72 | hr | 1401 | 2916 | 4245 | 0.6864 | 0.5790 |
| SK-BR-3 | Alpelisib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 2546 | 4245 | 0.6002 | 0.4522 |
| SK-BR-3 | Alpelisib | 10 | uM | LJP5 | 72 | hr | 1401 | 1593 | 4245 | 0.3756 | 0.0817 |
| SK-BR-3 | GDC-0980 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 1941 | 4245 | 0.4576 | 0.2251 |
| SK-BR-3 | GDC-0980 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 1500 | 4245 | 0.3536 | 0.0419 |
| SK-BR-3 | GDC-0980 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 1409 | 4245 | 0.3311 | -0.0011 |
| SK-BR-3 | GDC-0980 | 1.11 | uM | LJP5 | 72 | hr | 1401 | 1403 | 4245 | 0.3310 | -0.0002 |
| SK-BR-3 | GDC-0980 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 1419 | 4245 | 0.3340 | 0.0050 |
| SK-BR-3 | GDC-0980 | 10 | uM | LJP5 | 72 | hr | 1401 | 1272 | 4245 | 0.3007 | -0.0586 |
| SK-BR-3 | Mitoxantrone | 0.04 | uM | LJP5 | 72 | hr | 1401 | 1595 | 4245 | 0.3753 | 0.0810 |
| SK-BR-3 | Mitoxantrone | 0.04 | uM | LJP6 | 72 | hr | 1401 | 1585 | 4168 | 0.3803 | 0.0814 |
| SK-BR-3 | Mitoxantrone | 0.12 | uM | LJP5 | 72 | hr | 1401 | 1514 | 4245 | 0.3588 | 0.0513 |
| SK-BR-3 | Mitoxantrone | 0.12 | uM | LJP6 | 72 | hr | 1401 | 1434 | 4168 | 0.3445 | 0.0151 |
| SK-BR-3 | Mitoxantrone | 0.37 | uM | LJP5 | 72 | hr | 1401 | 1487 | 4245 | 0.3496 | 0.0340 |
| SK-BR-3 | Mitoxantrone | 0.37 | uM | LJP6 | 72 | hr | 1401 | 1351 | 4168 | 0.3244 | -0.0231 |