LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | ZSTK474 | 0.12 | uM | LJP6 | 72 | hr | 1097 | 2700 | 3673 | 0.7356 | 0.6766 |
| SK-BR-3 | ZSTK474 | 0.37 | uM | LJP6 | 72 | hr | 1401 | 1958 | 4168 | 0.4696 | 0.2362 |
| SK-BR-3 | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 1645 | 4168 | 0.3949 | 0.1075 |
| SK-BR-3 | ZSTK474 | 1.11 | uM | LJP6 | 72 | hr | 1401 | 1708 | 4168 | 0.4100 | 0.1342 |
| SK-BR-3 | ZSTK474 | 0.04 | uM | LJP6 | 72 | hr | 1401 | 3262 | 4168 | 0.7821 | 0.7091 |
| MCF7 | ZSTK474 | 0.04 | uM | LJP6 | 72 | hr | 1209 | 2257 | 4012 | 0.5628 | 0.4342 |
| SK-BR-3 | ZSTK474 | 0.12 | uM | LJP6 | 72 | hr | 1401 | 2371 | 4168 | 0.5690 | 0.3973 |
| Hs 578T | ZSTK474 | 0.04 | uM | LJP6 | 72 | hr | 658 | 2989 | 3761 | 0.7947 | 0.8253 |
| Hs 578T | ZSTK474 | 0.12 | uM | LJP6 | 72 | hr | 658 | 2500 | 3761 | 0.6649 | 0.7003 |
| MDA-MB-231 | ZSTK474 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 3300 | 4405 | 0.7503 | 0.7101 |
| MCF7 | ZSTK474 | 10 | uM | LJP6 | 72 | hr | 1209 | 925 | 4012 | 0.2310 | -0.1435 |
| MDA-MB-231 | YM 201636 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 3734 | 4660 | 0.7985 | 0.7746 |
| MDA-MB-231 | YM 201636 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 3223 | 4660 | 0.6888 | 0.6417 |
| MCF7 | YM 201636 | 10 | uM | LJP5 | 72 | hr | 1209 | 435 | 4203 | 0.1038 | -0.4341 |
| MDA-MB-231 | YM 201636 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 2698 | 4660 | 0.5776 | 0.4991 |
| MDA-MB-231 | YM 201636 | 10 | uM | LJP5 | 72 | hr | 1235 | 986 | 4660 | 0.2113 | -0.1132 |
| BT-20 | YM 201636 | 1.11 | uM | LJP5 | 72 | hr | 1097 | 2848 | 3846 | 0.7404 | 0.6933 |
| BT-20 | YM 201636 | 0.12 | uM | LJP5 | 72 | hr | 1097 | 3822 | 3846 | 0.9937 | 0.9927 |
| BT-20 | YM 201636 | 0.37 | uM | LJP5 | 72 | hr | 1097 | 3692 | 3846 | 0.9604 | 0.9557 |
| BT-20 | YM 201636 | 3.33 | uM | LJP5 | 72 | hr | 1097 | 2295 | 3846 | 0.5971 | 0.5036 |
| BT-20 | YM 201636 | 10 | uM | LJP5 | 72 | hr | 1097 | 1092 | 3846 | 0.2842 | -0.0036 |
| SK-BR-3 | YM 201636 | 10 | uM | LJP5 | 72 | hr | 1401 | 1942 | 4245 | 0.4570 | 0.2231 |
| SK-BR-3 | YM 201636 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 3632 | 4245 | 0.8563 | 0.8154 |
| MDA-MB-231 | YM 201636 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4204 | 4660 | 0.8999 | 0.8902 |
| MCF7 | YM 201636 | 0.04 | uM | LJP5 | 72 | hr | 1209 | 4290 | 4203 | 1.0216 | 1.0245 |