LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Selumetinib | 0.12 | uM | LJP6 | 72 | hr | 1401 | 4317 | 4168 | 1.0357 | 1.0453 |
| SK-BR-3 | Selumetinib | 0.37 | uM | LJP6 | 72 | hr | 1401 | 4343 | 4168 | 1.0418 | 1.0521 |
| SK-BR-3 | Selumetinib | 1.11 | uM | LJP6 | 72 | hr | 1401 | 4047 | 4168 | 0.9706 | 0.9620 |
| SK-BR-3 | Selumetinib | 3.33 | uM | LJP6 | 72 | hr | 1401 | 4365 | 4168 | 1.0469 | 1.0583 |
| SK-BR-3 | Selumetinib | 10 | uM | LJP6 | 72 | hr | 1401 | 4192 | 4168 | 1.0065 | 1.0081 |
| SK-BR-3 | MK2206 | 0.04 | uM | LJP6 | 72 | hr | 1401 | 3077 | 4168 | 0.7383 | 0.6486 |
| SK-BR-3 | MK2206 | 0.12 | uM | LJP6 | 72 | hr | 1401 | 2820 | 4168 | 0.6764 | 0.5596 |
| SK-BR-3 | MK2206 | 0.37 | uM | LJP6 | 72 | hr | 1401 | 2683 | 4168 | 0.6437 | 0.5110 |
| SK-BR-3 | MK2206 | 1.11 | uM | LJP6 | 72 | hr | 1401 | 2472 | 4168 | 0.5931 | 0.4346 |
| SK-BR-3 | MK2206 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 2185 | 4168 | 0.5243 | 0.3263 |
| SK-BR-3 | MK2206 | 10 | uM | LJP6 | 72 | hr | 1401 | 1297 | 4168 | 0.3113 | -0.0480 |
| SK-BR-3 | AZD-6482 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4191 | 4245 | 0.9876 | 0.9847 |
| SK-BR-3 | AZD-6482 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 3738 | 4245 | 0.8802 | 0.8459 |
| SK-BR-3 | AZD-6482 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 3999 | 4245 | 0.9415 | 0.9236 |
| SK-BR-3 | AZD-6482 | 1.11 | uM | LJP5 | 72 | hr | 1401 | 3566 | 4245 | 0.8390 | 0.7902 |
| SK-BR-3 | AZD-6482 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 2731 | 4245 | 0.6346 | 0.4815 |
| SK-BR-3 | AZD-6482 | 10 | uM | LJP5 | 72 | hr | 1401 | 1710 | 4245 | 0.3994 | 0.1166 |
| SK-BR-3 | NU7441 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4400 | 4245 | 1.0401 | 1.0532 |
| SK-BR-3 | NU7441 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 3973 | 4245 | 0.9416 | 0.9294 |
| SK-BR-3 | NU7441 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 3992 | 4245 | 0.9474 | 0.9368 |
| SK-BR-3 | NU7441 | 1.11 | uM | LJP5 | 72 | hr | 1401 | 3859 | 4245 | 0.9091 | 0.8840 |
| SK-BR-3 | NU7441 | 3.33 | uM | LJP5 | 72 | hr | 1401 | 3277 | 4245 | 0.7780 | 0.7103 |
| SK-BR-3 | NU7441 | 10 | uM | LJP5 | 72 | hr | 1401 | 1805 | 4245 | 0.4260 | 0.1714 |
| SK-BR-3 | OSI-027 | 0.04 | uM | LJP6 | 72 | hr | 1401 | 3017 | 4168 | 0.7239 | 0.6285 |
| SK-BR-3 | OSI-027 | 0.12 | uM | LJP6 | 72 | hr | 1401 | 1996 | 4168 | 0.4794 | 0.2520 |