LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Radicicol | 3.33 | uM | LJP6 | 72 | hr | 1209 | 1452 | 4012 | 0.3621 | 0.1112 |
| MCF7 | Radicicol | 10 | uM | LJP5 | 72 | hr | 1209 | 1010 | 4203 | 0.2409 | -0.0957 |
| MCF7 | Radicicol | 10 | uM | LJP6 | 72 | hr | 1209 | 954 | 4012 | 0.2381 | -0.1285 |
| MCF7 | Withaferin A | 0.04 | uM | LJP5 | 72 | hr | 1209 | 4135 | 4203 | 0.9851 | 0.9842 |
| MCF7 | Withaferin A | 0.04 | uM | LJP6 | 72 | hr | 1209 | 4048 | 4012 | 1.0081 | 1.0084 |
| MCF7 | Withaferin A | 0.12 | uM | LJP5 | 72 | hr | 1209 | 4381 | 4203 | 1.0450 | 1.0507 |
| MCF7 | Withaferin A | 0.12 | uM | LJP6 | 72 | hr | 1209 | 3460 | 4012 | 0.8634 | 0.8377 |
| MCF7 | Withaferin A | 0.37 | uM | LJP5 | 72 | hr | 1209 | 1706 | 4203 | 0.4063 | 0.2102 |
| MCF7 | Withaferin A | 0.37 | uM | LJP6 | 72 | hr | 1209 | 1696 | 4012 | 0.4234 | 0.2164 |
| MCF7 | Withaferin A | 1.11 | uM | LJP5 | 72 | hr | 1209 | 1364 | 4203 | 0.3253 | 0.0696 |
| MCF7 | Withaferin A | 1.11 | uM | LJP6 | 72 | hr | 1209 | 1327 | 4012 | 0.3307 | 0.0541 |
| MCF7 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 1209 | 527 | 4203 | 0.1258 | -0.3701 |
| MCF7 | Withaferin A | 3.33 | uM | LJP6 | 72 | hr | 1209 | 571 | 4012 | 0.1429 | -0.3521 |
| MCF7 | Withaferin A | 10 | uM | LJP5 | 72 | hr | 1209 | 744 | 4203 | 0.1780 | -0.2371 |
| MCF7 | Withaferin A | 10 | uM | LJP6 | 72 | hr | 1209 | 664 | 4012 | 0.1659 | -0.2930 |
| SK-BR-3 | Seliciclib | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4169 | 4245 | 0.9826 | 0.9786 |
| SK-BR-3 | Seliciclib | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4234 | 4245 | 0.9990 | 1.0004 |
| SK-BR-3 | Seliciclib | 0.37 | uM | LJP5 | 72 | hr | 1401 | 3923 | 4245 | 0.9229 | 0.9004 |
| SK-BR-3 | Seliciclib | 1.11 | uM | LJP5 | 72 | hr | 1401 | 3763 | 4245 | 0.8864 | 0.8542 |
| SK-BR-3 | Seliciclib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 3235 | 4245 | 0.7609 | 0.6836 |
| SK-BR-3 | Seliciclib | 10 | uM | LJP5 | 72 | hr | 1401 | 2209 | 4245 | 0.5182 | 0.3213 |
| SK-BR-3 | AT-7519 | 0.04 | uM | LJP6 | 72 | hr | 1401 | 2511 | 4168 | 0.6031 | 0.4499 |
| SK-BR-3 | AT-7519 | 0.12 | uM | LJP6 | 72 | hr | 1401 | 1469 | 4168 | 0.3528 | 0.0307 |
| SK-BR-3 | AT-7519 | 0.37 | uM | LJP6 | 72 | hr | 1401 | 1174 | 4168 | 0.2819 | -0.1064 |
| SK-BR-3 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 1401 | 953 | 4168 | 0.2287 | -0.2181 |