LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Radicicol | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1609 | 5445 | 0.2962 | 0.0777 |
| MCF7 | Radicicol | 10 | uM | LJP5 | 72 | hr | 1389 | 1296 | 5905 | 0.2194 | -0.0332 |
| MCF7 | Radicicol | 10 | uM | LJP6 | 72 | hr | 1389 | 1223 | 5445 | 0.2245 | -0.0645 |
| MCF7 | Withaferin A | 0.04 | uM | LJP5 | 72 | hr | 1389 | 5874 | 5905 | 0.9974 | 0.9957 |
| MCF7 | Withaferin A | 0.04 | uM | LJP6 | 72 | hr | 1389 | 5669 | 5445 | 1.0438 | 1.0447 |
| MCF7 | Withaferin A | 0.12 | uM | LJP5 | 72 | hr | 1389 | 5397 | 5905 | 0.9142 | 0.9161 |
| MCF7 | Withaferin A | 0.12 | uM | LJP6 | 72 | hr | 1389 | 5200 | 5445 | 0.9551 | 0.9535 |
| MCF7 | Withaferin A | 0.37 | uM | LJP5 | 72 | hr | 1389 | 2889 | 5905 | 0.4895 | 0.4204 |
| MCF7 | Withaferin A | 0.37 | uM | LJP6 | 72 | hr | 1389 | 2590 | 5445 | 0.4757 | 0.3710 |
| MCF7 | Withaferin A | 1.11 | uM | LJP5 | 72 | hr | 1389 | 1758 | 5905 | 0.2976 | 0.1190 |
| MCF7 | Withaferin A | 1.11 | uM | LJP6 | 72 | hr | 1389 | 1678 | 5445 | 0.3079 | 0.0988 |
| MCF7 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 1389 | 1031 | 5905 | 0.1753 | -0.1344 |
| MCF7 | Withaferin A | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1049 | 5445 | 0.1929 | -0.1334 |
| MCF7 | Withaferin A | 10 | uM | LJP5 | 72 | hr | 1389 | 1192 | 5905 | 0.2018 | -0.0709 |
| MCF7 | Withaferin A | 10 | uM | LJP6 | 72 | hr | 1389 | 1181 | 5445 | 0.2165 | -0.0829 |
| SK-BR-3 | Seliciclib | 0.04 | uM | LJP5 | 72 | hr | 2543 | 5757 | 5752 | 1.0010 | 1.0016 |
| SK-BR-3 | Seliciclib | 0.12 | uM | LJP5 | 72 | hr | 2543 | 5868 | 5752 | 1.0202 | 1.0343 |
| SK-BR-3 | Seliciclib | 0.37 | uM | LJP5 | 72 | hr | 2543 | 5645 | 5752 | 0.9815 | 0.9682 |
| SK-BR-3 | Seliciclib | 1.11 | uM | LJP5 | 72 | hr | 2543 | 5394 | 5752 | 0.9377 | 0.8937 |
| SK-BR-3 | Seliciclib | 3.33 | uM | LJP5 | 72 | hr | 2543 | 4738 | 5752 | 0.8238 | 0.6963 |
| SK-BR-3 | Seliciclib | 10 | uM | LJP5 | 72 | hr | 2543 | 2998 | 5752 | 0.5213 | 0.1501 |
| SK-BR-3 | AT-7519 | 0.04 | uM | LJP6 | 72 | hr | 2543 | 5140 | 5418 | 0.9491 | 0.9072 |
| SK-BR-3 | AT-7519 | 0.12 | uM | LJP6 | 72 | hr | 2543 | 3234 | 5418 | 0.5975 | 0.2473 |
| SK-BR-3 | AT-7519 | 0.37 | uM | LJP6 | 72 | hr | 2543 | 2056 | 5418 | 0.3799 | -0.1769 |
| SK-BR-3 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 2543 | 1298 | 5418 | 0.2398 | -0.4606 |