LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Canertinib | 0.04 | uM | LJP6 | 72 | hr | 1389 | 5411 | 5445 | 0.9908 | 0.9849 |
| MCF7 | Canertinib | 0.12 | uM | LJP6 | 72 | hr | 1389 | 4810 | 5445 | 0.8814 | 0.8717 |
| MCF7 | Canertinib | 0.37 | uM | LJP6 | 72 | hr | 1389 | 4622 | 5445 | 0.8472 | 0.8355 |
| MCF7 | Canertinib | 1.11 | uM | LJP6 | 72 | hr | 1389 | 3882 | 5445 | 0.7098 | 0.6745 |
| MCF7 | Canertinib | 3.33 | uM | LJP6 | 72 | hr | 1389 | 3496 | 5445 | 0.6401 | 0.5910 |
| MCF7 | Canertinib | 10 | uM | LJP6 | 72 | hr | 1389 | 566 | 5445 | 0.1043 | -0.3663 |
| MCF7 | NVP-AEW541 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 5919 | 5905 | 1.0037 | 1.0035 |
| MCF7 | NVP-AEW541 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 5446 | 5905 | 0.9216 | 0.9225 |
| MCF7 | NVP-AEW541 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 3387 | 5905 | 0.5716 | 0.5240 |
| MCF7 | NVP-AEW541 | 1.11 | uM | LJP5 | 72 | hr | 1389 | 3110 | 5905 | 0.5261 | 0.4696 |
| MCF7 | NVP-AEW541 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 3185 | 5905 | 0.5393 | 0.4876 |
| MCF7 | NVP-AEW541 | 10 | uM | LJP5 | 72 | hr | 1389 | 1518 | 5905 | 0.2565 | 0.0407 |
| MCF7 | PHA-665752 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 6381 | 5905 | 1.0798 | 1.0742 |
| MCF7 | PHA-665752 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 6367 | 5905 | 1.0773 | 1.0717 |
| MCF7 | PHA-665752 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 6395 | 5905 | 1.0826 | 1.0771 |
| MCF7 | PHA-665752 | 1.11 | uM | LJP5 | 72 | hr | 1389 | 6391 | 5905 | 1.0813 | 1.0751 |
| MCF7 | PHA-665752 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 5626 | 5905 | 0.9536 | 0.9551 |
| MCF7 | PHA-665752 | 10 | uM | LJP5 | 72 | hr | 1389 | 4976 | 5905 | 0.8421 | 0.8414 |
| MCF7 | PI103 | 0.04 | uM | LJP6 | 72 | hr | 1389 | 4179 | 5445 | 0.7662 | 0.7453 |
| MCF7 | PI103 | 0.12 | uM | LJP6 | 72 | hr | 1389 | 2880 | 5445 | 0.5259 | 0.4374 |
| MCF7 | PI103 | 0.37 | uM | LJP6 | 72 | hr | 1389 | 1654 | 5445 | 0.3030 | 0.0891 |
| MCF7 | PI103 | 1.11 | uM | LJP6 | 72 | hr | 1389 | 1305 | 5445 | 0.2399 | -0.0317 |
| MCF7 | PI103 | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1282 | 5445 | 0.2355 | -0.0407 |
| MCF7 | PI103 | 10 | uM | LJP6 | 72 | hr | 1389 | 1130 | 5445 | 0.2077 | -0.1001 |
| MCF7 | Dovitinib | 0.04 | uM | LJP5 | 72 | hr | 1389 | 5070 | 5905 | 0.8580 | 0.8580 |