LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1389 | 803 | 5445 | 0.1477 | -0.2433 |
| MDA-MB-231 | A443654 | 1.11 | uM | LJP6 | 72 | hr | 1311 | 1147 | 4935 | 0.2326 | -0.0682 |
| MCF7 | A443654 | 1.11 | uM | LJP6 | 72 | hr | 1389 | 804 | 5445 | 0.1473 | -0.2445 |
| MCF7 | A443654 | 0.12 | uM | LJP6 | 72 | hr | 1389 | 1052 | 5445 | 0.1933 | -0.1323 |
| MDA-MB-231 | A443654 | 10 | uM | LJP6 | 72 | hr | 1311 | 454 | 4935 | 0.0922 | -0.4257 |
| SK-BR-3 | A443654 | 0.12 | uM | LJP6 | 72 | hr | 2543 | 1373 | 5418 | 0.2534 | -0.4322 |
| MCF7 | A443654 | 0.37 | uM | LJP6 | 72 | hr | 1389 | 886 | 5445 | 0.1622 | -0.2067 |
| MDA-MB-231 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1311 | 1131 | 4935 | 0.2292 | -0.0750 |
| MCF7 | A443654 | 0.04 | uM | LJP6 | 72 | hr | 1389 | 1385 | 5445 | 0.2540 | -0.0037 |
| Hs 578T | A443654 | 1.11 | uM | LJP6 | 72 | hr | 765 | 397 | 3101 | 0.1281 | -0.2776 |
| Hs 578T | A443654 | 3.33 | uM | LJP6 | 72 | hr | 765 | 321 | 3101 | 0.1036 | -0.3494 |
| MDA-MB-231 | Afatinib | 1.11 | uM | LJP6 | 72 | hr | 1311 | 3443 | 4935 | 0.6977 | 0.6567 |
| BT-20 | Afatinib | 1.11 | uM | LJP6 | 72 | hr | 1334 | 3442 | 3925 | 0.8768 | 0.8370 |
| MDA-MB-231 | Afatinib | 3.33 | uM | LJP6 | 72 | hr | 1311 | 2811 | 4935 | 0.5699 | 0.4902 |
| MDA-MB-231 | Afatinib | 10 | uM | LJP6 | 72 | hr | 1311 | 808 | 4935 | 0.1639 | -0.2238 |
| BT-20 | Afatinib | 3.33 | uM | LJP6 | 72 | hr | 1334 | 3377 | 3925 | 0.8604 | 0.8152 |
| MDA-MB-231 | Afatinib | 0.04 | uM | LJP6 | 72 | hr | 1311 | 4376 | 4935 | 0.8868 | 0.8782 |
| BT-20 | Afatinib | 0.12 | uM | LJP6 | 72 | hr | 1334 | 3247 | 3925 | 0.8273 | 0.7705 |
| BT-20 | Afatinib | 0.37 | uM | LJP6 | 72 | hr | 1334 | 3305 | 3925 | 0.8421 | 0.7906 |
| BT-20 | Afatinib | 10 | uM | LJP6 | 72 | hr | 1334 | 2081 | 3925 | 0.5307 | 0.3294 |
| SK-BR-3 | Afatinib | 3.33 | uM | LJP6 | 72 | hr | 2543 | 1938 | 5418 | 0.3580 | -0.2206 |
| MCF7 | Afatinib | 10 | uM | LJP6 | 72 | hr | 1389 | 760 | 5445 | 0.1389 | -0.2677 |
| SK-BR-3 | Afatinib | 10 | uM | LJP6 | 72 | hr | 2543 | 1731 | 5418 | 0.3198 | -0.2973 |
| MCF7 | Afatinib | 0.04 | uM | LJP6 | 72 | hr | 1389 | 4541 | 5445 | 0.8383 | 0.8287 |
| MCF7 | Afatinib | 0.12 | uM | LJP6 | 72 | hr | 1389 | 4829 | 5445 | 0.8918 | 0.8866 |