LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Neratinib | 0.37 | uM | LJP5 | 72 | hr | 2543 | 1519 | 5752 | 0.2641 | -0.3546 |
| MCF7 | WZ3105 | 10 | uM | LJP5 | 72 | hr | 1389 | 562 | 5905 | 0.0956 | -0.3530 |
| BT-20 | Torin2 | 10 | uM | LJP5 | 72 | hr | 1334 | 667 | 4033 | 0.1658 | -0.3523 |
| SK-BR-3 | AZD8055 | 10 | uM | LJP6 | 72 | hr | 2543 | 1586 | 5418 | 0.2925 | -0.3523 |
| MCF7 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 1389 | 595 | 5445 | 0.1094 | -0.3514 |
| SK-BR-3 | PF431396 | 10 | uM | LJP5 | 72 | hr | 2543 | 1530 | 5752 | 0.2661 | -0.3506 |
| Hs 578T | A443654 | 3.33 | uM | LJP6 | 72 | hr | 765 | 321 | 3101 | 0.1036 | -0.3494 |
| BT-20 | PHA-793887 | 10 | uM | LJP6 | 72 | hr | 1334 | 689 | 3925 | 0.1759 | -0.3491 |
| Hs 578T | Fedratinib | 10 | uM | LJP5 | 72 | hr | 765 | 321 | 3148 | 0.1021 | -0.3478 |
| BT-20 | WH-4-025 | 10 | uM | LJP5 | 72 | hr | 1334 | 676 | 4033 | 0.1677 | -0.3473 |
| BT-20 | BI-2536 | 0.04 | uM | LJP6 | 72 | hr | 1334 | 687 | 3925 | 0.1751 | -0.3472 |
| Hs 578T | Withaferin A | 10 | uM | LJP5 | 72 | hr | 765 | 322 | 3148 | 0.1025 | -0.3466 |
| BT-20 | BI-2536 | 1.11 | uM | LJP6 | 72 | hr | 1334 | 688 | 3925 | 0.1754 | -0.3465 |
| Hs 578T | Withaferin A | 10 | uM | LJP6 | 72 | hr | 765 | 326 | 3101 | 0.1050 | -0.3465 |
| MCF7 | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 1389 | 577 | 5905 | 0.0976 | -0.3443 |
| SK-BR-3 | JNK-9L | 10 | uM | LJP6 | 72 | hr | 2543 | 1607 | 5418 | 0.2965 | -0.3442 |
| MCF 10A | A443654 | 10 | uM | LJP6 | 72 | hr | 1694 | 538 | 11217 | 0.0480 | -0.3439 |
| SK-BR-3 | A443654 | 0.04 | uM | LJP6 | 72 | hr | 2543 | 1613 | 5418 | 0.2978 | -0.3416 |
| SK-BR-3 | Mitoxantrone | 0.04 | uM | LJP6 | 72 | hr | 2543 | 1620 | 5418 | 0.2994 | -0.3386 |
| SK-BR-3 | PI103 | 10 | uM | LJP6 | 72 | hr | 2543 | 1624 | 5418 | 0.2995 | -0.3382 |
| MCF7 | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 1389 | 618 | 5445 | 0.1142 | -0.3372 |
| BT-20 | JNK-9L | 10 | uM | LJP6 | 72 | hr | 1334 | 704 | 3925 | 0.1794 | -0.3370 |
| Hs 578T | Buparlisib | 10 | uM | LJP5 | 72 | hr | 765 | 331 | 3148 | 0.1051 | -0.3367 |
| SK-BR-3 | Neratinib | 0.12 | uM | LJP5 | 72 | hr | 2543 | 1569 | 5752 | 0.2729 | -0.3365 |
| MCF7 | Geldanamycin | 10 | uM | LJP6 | 72 | hr | 1389 | 621 | 5445 | 0.1143 | -0.3363 |