LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Selumetinib | 0.12 | uM | LJP6 | 72 | hr | 2543 | 5492 | 5418 | 1.0144 | 1.0281 |
| SK-BR-3 | Selumetinib | 0.37 | uM | LJP6 | 72 | hr | 2543 | 5549 | 5418 | 1.0246 | 1.0461 |
| SK-BR-3 | Selumetinib | 1.11 | uM | LJP6 | 72 | hr | 2543 | 5511 | 5418 | 1.0173 | 1.0317 |
| SK-BR-3 | Selumetinib | 3.33 | uM | LJP6 | 72 | hr | 2543 | 5397 | 5418 | 0.9971 | 0.9968 |
| SK-BR-3 | Selumetinib | 10 | uM | LJP6 | 72 | hr | 2543 | 5264 | 5418 | 0.9725 | 0.9513 |
| SK-BR-3 | MK2206 | 0.04 | uM | LJP6 | 72 | hr | 2543 | 4652 | 5418 | 0.8593 | 0.7415 |
| SK-BR-3 | MK2206 | 0.12 | uM | LJP6 | 72 | hr | 2543 | 4103 | 5418 | 0.7576 | 0.5509 |
| SK-BR-3 | MK2206 | 0.37 | uM | LJP6 | 72 | hr | 2543 | 3718 | 5418 | 0.6864 | 0.4161 |
| SK-BR-3 | MK2206 | 1.11 | uM | LJP6 | 72 | hr | 2543 | 3610 | 5418 | 0.6667 | 0.3792 |
| SK-BR-3 | MK2206 | 3.33 | uM | LJP6 | 72 | hr | 2543 | 3143 | 5418 | 0.5809 | 0.2158 |
| SK-BR-3 | MK2206 | 10 | uM | LJP6 | 72 | hr | 2543 | 2333 | 5418 | 0.4308 | -0.0763 |
| SK-BR-3 | AZD-6482 | 0.04 | uM | LJP5 | 72 | hr | 2543 | 5673 | 5752 | 0.9864 | 0.9767 |
| SK-BR-3 | AZD-6482 | 0.12 | uM | LJP5 | 72 | hr | 2543 | 5521 | 5752 | 0.9599 | 0.9315 |
| SK-BR-3 | AZD-6482 | 0.37 | uM | LJP5 | 72 | hr | 2543 | 5751 | 5752 | 0.9999 | 0.9997 |
| SK-BR-3 | AZD-6482 | 1.11 | uM | LJP5 | 72 | hr | 2543 | 5513 | 5752 | 0.9584 | 0.9290 |
| SK-BR-3 | AZD-6482 | 3.33 | uM | LJP5 | 72 | hr | 2543 | 3544 | 5752 | 0.6163 | 0.3248 |
| SK-BR-3 | AZD-6482 | 10 | uM | LJP5 | 72 | hr | 2543 | 1693 | 5752 | 0.2945 | -0.2933 |
| SK-BR-3 | NU7441 | 0.04 | uM | LJP5 | 72 | hr | 2543 | 5767 | 5752 | 1.0025 | 1.0042 |
| SK-BR-3 | NU7441 | 0.12 | uM | LJP5 | 72 | hr | 2543 | 5567 | 5752 | 0.9679 | 0.9453 |
| SK-BR-3 | NU7441 | 0.37 | uM | LJP5 | 72 | hr | 2543 | 5232 | 5752 | 0.9096 | 0.8451 |
| SK-BR-3 | NU7441 | 1.11 | uM | LJP5 | 72 | hr | 2543 | 4652 | 5752 | 0.8088 | 0.6692 |
| SK-BR-3 | NU7441 | 3.33 | uM | LJP5 | 72 | hr | 2543 | 4653 | 5752 | 0.8089 | 0.6698 |
| SK-BR-3 | NU7441 | 10 | uM | LJP5 | 72 | hr | 2543 | 3417 | 5752 | 0.5942 | 0.2852 |
| SK-BR-3 | OSI-027 | 0.04 | uM | LJP6 | 72 | hr | 2543 | 4867 | 5418 | 0.8992 | 0.8159 |
| SK-BR-3 | OSI-027 | 0.12 | uM | LJP6 | 72 | hr | 2543 | 3457 | 5418 | 0.6386 | 0.3258 |