LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Linifanib | 0.12 | uM | LJP6 | 72 | hr | 1389 | 4928 | 5445 | 0.9055 | 0.9014 |
| MCF7 | Linifanib | 0.37 | uM | LJP6 | 72 | hr | 1389 | 5056 | 5445 | 0.9277 | 0.9244 |
| MCF7 | Linifanib | 1.11 | uM | LJP6 | 72 | hr | 1389 | 4951 | 5445 | 0.9088 | 0.9042 |
| MCF7 | Linifanib | 3.33 | uM | LJP6 | 72 | hr | 1389 | 4764 | 5445 | 0.8750 | 0.8681 |
| MCF7 | Linifanib | 10 | uM | LJP6 | 72 | hr | 1389 | 1841 | 5445 | 0.3379 | 0.1520 |
| MCF7 | PIK-93 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 6398 | 5905 | 1.0835 | 1.0784 |
| MCF7 | PIK-93 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 6076 | 5905 | 1.0287 | 1.0272 |
| MCF7 | PIK-93 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 6152 | 5905 | 1.0408 | 1.0376 |
| MCF7 | PIK-93 | 1.11 | uM | LJP5 | 72 | hr | 1389 | 5797 | 5905 | 0.9821 | 0.9830 |
| MCF7 | PIK-93 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 3444 | 5905 | 0.5828 | 0.5436 |
| MCF7 | PIK-93 | 10 | uM | LJP5 | 72 | hr | 1389 | 1850 | 5905 | 0.3130 | 0.1460 |
| MCF7 | Dactolisib | 0.04 | uM | LJP5 | 72 | hr | 1389 | 2132 | 5905 | 0.3610 | 0.2274 |
| MCF7 | Dactolisib | 0.12 | uM | LJP5 | 72 | hr | 1389 | 2050 | 5905 | 0.3473 | 0.2049 |
| MCF7 | Dactolisib | 0.37 | uM | LJP5 | 72 | hr | 1389 | 1790 | 5905 | 0.3031 | 0.1289 |
| MCF7 | Dactolisib | 1.11 | uM | LJP5 | 72 | hr | 1389 | 1784 | 5905 | 0.3023 | 0.1274 |
| MCF7 | Dactolisib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 1861 | 5905 | 0.3151 | 0.1500 |
| MCF7 | Dactolisib | 10 | uM | LJP5 | 72 | hr | 1389 | 1854 | 5905 | 0.3139 | 0.1480 |
| MCF7 | Alpelisib | 0.04 | uM | LJP5 | 72 | hr | 1389 | 5602 | 5905 | 0.9492 | 0.9509 |
| MCF7 | Alpelisib | 0.12 | uM | LJP5 | 72 | hr | 1389 | 4433 | 5905 | 0.7507 | 0.7432 |
| MCF7 | Alpelisib | 0.37 | uM | LJP5 | 72 | hr | 1389 | 3867 | 5905 | 0.6546 | 0.6323 |
| MCF7 | Alpelisib | 1.11 | uM | LJP5 | 72 | hr | 1389 | 3048 | 5905 | 0.5157 | 0.4557 |
| MCF7 | Alpelisib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 2436 | 5905 | 0.4120 | 0.3070 |
| MCF7 | Alpelisib | 10 | uM | LJP5 | 72 | hr | 1389 | 1460 | 5905 | 0.2471 | 0.0234 |
| MCF7 | GDC-0980 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 2176 | 5905 | 0.3690 | 0.2403 |
| MCF7 | GDC-0980 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 1457 | 5905 | 0.2467 | 0.0229 |