LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
BT-20 Afatinib
1.11
uM
LJP6
 72
hr
 1657 5087 5383 0.9459 0.9359
SK-BR-3 Afatinib
1.11
uM
LJP6
 72
hr
 1476 1506 3643 0.4131 0.0126
BT-20 Afatinib
3.33
uM
LJP6
 72
hr
 1657 4854 5383 0.9034 0.8832
MDA-MB-231 Afatinib
3.33
uM
LJP6
 72
hr
 868 2182 3556 0.6146 0.5740
MCF7 Afatinib
1.11
uM
LJP6
 72
hr
 1235 3186 4056 0.7852 0.7355
Hs 578T Afatinib
0.37
uM
LJP6
 72
hr
 929 3030 3216 0.9421 0.9342
MCF 10A Afatinib
0.04
uM
LJP6
 72
hr
 513 351 10473 0.0335 -0.0847
MDA-MB-231 Afatinib
0.12
uM
LJP6
 72
hr
 868 2948 3556 0.8290 0.8237
SK-BR-3 Afatinib
3.33
uM
LJP6
 72
hr
 1476 1484 3643 0.4075 0.0023
Hs 578T Afatinib
0.12
uM
LJP6
 72
hr
 929 3002 3216 0.9333 0.9243
Hs 578T Afatinib
0.04
uM
LJP6
 72
hr
 929 3069 3216 0.9542 0.9483
MCF7 Afatinib
0.04
uM
LJP6
 72
hr
 1235 2830 4056 0.6983 0.6221
MDA-MB-231 Afatinib
0.04
uM
LJP6
 72
hr
 868 2549 3556 0.7165 0.6971
SK-BR-3 Afatinib
0.04
uM
LJP6
 72
hr
 1476 1371 3643 0.3762 -0.0579
MCF7 Afatinib
0.12
uM
LJP6
 72
hr
 1235 2890 4056 0.7125 0.6409
SK-BR-3 Afatinib
0.12
uM
LJP6
 72
hr
 1476 1324 3643 0.3644 -0.0802
MDA-MB-231 Afatinib
1.11
uM
LJP6
 72
hr
 868 2626 3556 0.7383 0.7222
MDA-MB-231 Afatinib
0.37
uM
LJP6
 72
hr
 868 2774 3556 0.7803 0.7690
MCF7 Afatinib
10
uM
LJP6
 72
hr
 1235 664 4056 0.1637 -0.3041
MCF7 Afatinib
0.37
uM
LJP6
 72
hr
 1235 3301 4056 0.8145 0.7745
BT-20 Afatinib
10
uM
LJP6
 72
hr
 1657 1569 5383 0.2917 -0.0317
Hs 578T Afatinib
1.11
uM
LJP6
 72
hr
 929 2985 3216 0.9281 0.9179
MDA-MB-231 Alpelisib
3.33
uM
LJP5
 72
hr
 868 3000 3410 0.8798 0.8743
BT-20 Alpelisib
3.33
uM
LJP5
 72
hr
 1657 2120 5588 0.3796 0.1505
SK-BR-3 Alpelisib
10
uM
LJP5
 72
hr
 1476 1181 3772 0.3133 -0.1523