LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Mitoxantrone | 1.11 | uM | LJP5 | 72 | hr | 513 | 387 | 10362 | 0.0373 | -0.0633 |
| MCF 10A | Geldanamycin | 3.33 | uM | LJP6 | 72 | hr | 513 | 393 | 10473 | 0.0375 | -0.0601 |
| MCF 10A | Geldanamycin | 3.33 | uM | LJP5 | 72 | hr | 513 | 389 | 10362 | 0.0376 | -0.0630 |
| MCF 10A | Omipalisib | 10 | uM | LJP6 | 72 | hr | 513 | 397 | 10473 | 0.0379 | -0.0574 |
| MCF 10A | PD0325901 | 10 | uM | LJP6 | 72 | hr | 513 | 398 | 10473 | 0.0380 | -0.0571 |
| MCF 10A | CGP60474 | 10 | uM | LJP6 | 72 | hr | 513 | 402 | 10473 | 0.0384 | -0.0616 |
| MCF 10A | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 513 | 403 | 10362 | 0.0389 | -0.0545 |
| MCF 10A | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 513 | 407 | 10473 | 0.0389 | -0.0529 |
| MCF 10A | SNS-032 | 10 | uM | LJP6 | 72 | hr | 513 | 407 | 10473 | 0.0389 | -0.0534 |
| MCF 10A | Dasatinib | 1.11 | uM | LJP6 | 72 | hr | 513 | 410 | 10473 | 0.0392 | -0.0505 |
| MCF 10A | A443654 | 10 | uM | LJP6 | 72 | hr | 513 | 415 | 10473 | 0.0397 | -0.0489 |
| MCF 10A | Radicicol | 10 | uM | LJP6 | 72 | hr | 513 | 419 | 10473 | 0.0400 | -0.0461 |
| MCF 10A | Afatinib | 0.12 | uM | LJP6 | 72 | hr | 513 | 427 | 10473 | 0.0408 | -0.0420 |
| MCF 10A | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 513 | 431 | 10473 | 0.0412 | -0.0395 |
| MCF 10A | A443654 | 1.11 | uM | LJP6 | 72 | hr | 513 | 445 | 10473 | 0.0425 | -0.0324 |
| MCF 10A | Celastrol | 3.33 | uM | LJP6 | 72 | hr | 513 | 450 | 10473 | 0.0430 | -0.0312 |
| MCF 10A | Withaferin A | 1.11 | uM | LJP5 | 72 | hr | 513 | 446 | 10362 | 0.0431 | -0.0317 |
| MCF 10A | AZD8330 | 0.04 | uM | LJP5 | 72 | hr | 513 | 447 | 10362 | 0.0431 | -0.0330 |
| MCF 10A | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 513 | 452 | 10473 | 0.0432 | -0.0298 |
| MCF 10A | GSK1059615 | 3.33 | uM | LJP6 | 72 | hr | 513 | 459 | 10473 | 0.0438 | -0.0260 |
| MCF 10A | Mitoxantrone | 1.11 | uM | LJP6 | 72 | hr | 513 | 458 | 10473 | 0.0438 | -0.0267 |
| MCF 10A | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 513 | 464 | 10473 | 0.0443 | -0.0231 |
| MCF 10A | Alvocidib | 10 | uM | LJP6 | 72 | hr | 513 | 467 | 10473 | 0.0447 | -0.0214 |
| MCF 10A | Foretinib | 10 | uM | LJP5 | 72 | hr | 513 | 463 | 10362 | 0.0447 | -0.0245 |
| MCF 10A | Luminespib | 1.11 | uM | LJP5 | 72 | hr | 513 | 465 | 10362 | 0.0449 | -0.0229 |