LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Neratinib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 2436 | 4267 | 0.5710 | 0.4617 |
| MCF7 | Neratinib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 2031 | 4267 | 0.4761 | 0.3201 |
| MCF7 | Neratinib | 10 | uM | LJP5 | 72 | hr | 1235 | 1169 | 4267 | 0.2741 | -0.0312 |
| MCF7 | JW-7-24-1 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 2487 | 4056 | 0.6129 | 0.5030 |
| MCF7 | JW-7-24-1 | 0.12 | uM | LJP6 | 72 | hr | 1235 | 2410 | 4056 | 0.5943 | 0.4765 |
| MCF7 | JW-7-24-1 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 1837 | 4056 | 0.4528 | 0.2600 |
| MCF7 | JW-7-24-1 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1666 | 4056 | 0.4106 | 0.1902 |
| MCF7 | JW-7-24-1 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1581 | 4056 | 0.3904 | 0.1550 |
| MCF7 | JW-7-24-1 | 10 | uM | LJP6 | 72 | hr | 1235 | 962 | 4056 | 0.2376 | -0.1361 |
| MCF7 | Dasatinib | 0.04 | uM | LJP5 | 72 | hr | 1235 | 2621 | 4267 | 0.6157 | 0.5235 |
| MCF7 | Dasatinib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 1127 | 4056 | 0.2781 | -0.0520 |
| MCF7 | Dasatinib | 0.12 | uM | LJP5 | 72 | hr | 1235 | 1273 | 4267 | 0.2988 | 0.0173 |
| MCF7 | Dasatinib | 0.12 | uM | LJP6 | 72 | hr | 1235 | 989 | 4056 | 0.2442 | -0.1218 |
| MCF7 | Dasatinib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 906 | 4267 | 0.2127 | -0.1589 |
| MCF7 | Dasatinib | 0.37 | uM | LJP6 | 72 | hr | 1235 | 972 | 4056 | 0.2395 | -0.1308 |
| MCF7 | Dasatinib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 999 | 4267 | 0.2344 | -0.1123 |
| MCF7 | Dasatinib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 1065 | 4056 | 0.2631 | -0.0831 |
| MCF7 | Dasatinib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 972 | 4267 | 0.2280 | -0.1257 |
| MCF7 | Dasatinib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 916 | 4056 | 0.2260 | -0.1601 |
| MCF7 | Dasatinib | 10 | uM | LJP5 | 72 | hr | 1235 | 918 | 4267 | 0.2150 | -0.1538 |
| MCF7 | Dasatinib | 10 | uM | LJP6 | 72 | hr | 1235 | 786 | 4056 | 0.1938 | -0.2317 |
| MCF7 | Tozasertib | 0.04 | uM | LJP5 | 72 | hr | 1235 | 1440 | 4267 | 0.3377 | 0.0894 |
| MCF7 | Tozasertib | 0.12 | uM | LJP5 | 72 | hr | 1235 | 1383 | 4267 | 0.3244 | 0.0653 |
| MCF7 | Tozasertib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 1483 | 4267 | 0.3479 | 0.1079 |
| MCF7 | Tozasertib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 1368 | 4267 | 0.3208 | 0.0586 |