LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 9 of 15: Cell count and normalized growth rate inhibition values within biological replicate 2. - Dataset (ID:20246)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Replicate Assay Well Timepoint Timepoint Unit Total Cell Count Before Treatment Total Cell Count After Treatment Total Control Cell Count Relative Cell Count Normalized Growth Rate Inhibition Value
MDA-MB-231 Trametinib
3.33
uM
LJP5
 2
P20
 72
hr
 1311 1767 5100 0.3465 0.1643
MDA-MB-231 Trametinib
3.33
uM
LJP5
 3
P20
 72
hr
 1311 1795 5010 0.3582 0.1761
MDA-MB-231 Trametinib
10
uM
LJP5
 1
P19
 72
hr
 1311 1759 5128 0.3430 0.1609
MDA-MB-231 Trametinib
10
uM
LJP5
 2
P19
 72
hr
 1311 1636 5100 0.3208 0.1194
MDA-MB-231 Trametinib
10
uM
LJP5
 3
P19
 72
hr
 1311 1655 5010 0.3303 0.1278
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 1
N06
 72
hr
 1311 3100 4870 0.6365 0.5753
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 2
N06
 72
hr
 1311 2907 4961 0.5859 0.5138
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 3
N06
 72
hr
 1311 3136 4973 0.6305 0.5735
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 1
N05
 72
hr
 1311 2282 4870 0.4686 0.3399
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 2
N05
 72
hr
 1311 2239 4961 0.4513 0.3213
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 3
N05
 72
hr
 1311 2175 4973 0.4373 0.3008
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 1
N04
 72
hr
 1311 1417 4870 0.2910 0.0416
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 2
N04
 72
hr
 1311 1654 4961 0.3334 0.1284
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 3
N04
 72
hr
 1311 1513 4973 0.3042 0.0771
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 1
N03
 72
hr
 1311 1225 4870 0.2515 -0.0355
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 2
N03
 72
hr
 1311 1089 4961 0.2195 -0.0924
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 3
N03
 72
hr
 1311 1058 4973 0.2127 -0.1058
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 1
N02
 72
hr
 1311 921 4870 0.1891 -0.1704
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 2
N02
 72
hr
 1311 810 4961 0.1633 -0.2221
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 3
N02
 72
hr
 1311 933 4973 0.1876 -0.1624
MDA-MB-231 Omipalisib
10
uM
LJP6
 1
N01
 72
hr
 1311 650 4870 0.1335 -0.3100
MDA-MB-231 Omipalisib
10
uM
LJP6
 2
N01
 72
hr
 1311 581 4961 0.1171 -0.3458
MDA-MB-231 Omipalisib
10
uM
LJP6
 3
N01
 72
hr
 1311 649 4973 0.1305 -0.3065
MDA-MB-231 Buparlisib
0.04
uM
LJP5
 1
H06
 72
hr
 1311 5345 5128 1.0422 1.0425
MDA-MB-231 Buparlisib
0.04
uM
LJP5
 2
H06
 72
hr
 1311 5053 5100 0.9908 0.9906