LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. - Dataset (ID:20241)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Canertinib | 10.0 | uM | LJP6 | 72 | hr | 1694 | 115 | 11155 | 0.0104 | -0.1668 |
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 765 | 172 | 3124 | 0.0550 | -0.2514 |
| Hs 578T | HG-6-64-01 | 10.0 | uM | LJP6 | 72 | hr | 765 | 174 | 3124 | 0.0559 | -0.2502 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 765 | 189 | 3124 | 0.0606 | -0.2440 |
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 765 | 208 | 3124 | 0.0668 | -0.2358 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 765 | 212 | 3124 | 0.0681 | -0.2341 |
| Hs 578T | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 765 | 218 | 3124 | 0.0698 | -0.2319 |
| Hs 578T | WH-4-025 | 10.0 | uM | LJP5 | 72 | hr | 765 | 226 | 3124 | 0.0723 | -0.2285 |
| Hs 578T | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 765 | 230 | 3124 | 0.0738 | -0.2265 |
| BT-20 | A443654 | 10.0 | uM | LJP6 | 72 | hr | 1334 | 232 | 3970 | 0.0586 | -0.4180 |
| Hs 578T | Canertinib | 10.0 | uM | LJP6 | 72 | hr | 765 | 240 | 3124 | 0.0770 | -0.2222 |
| MCF 10A | Withaferin A | 10.0 | uM | LJP6 | 72 | hr | 1694 | 241 | 11155 | 0.0216 | -0.1536 |
| MCF 10A | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1694 | 253 | 11155 | 0.0227 | -0.1523 |
| Hs 578T | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 765 | 266 | 3124 | 0.0852 | -0.2114 |
| Hs 578T | A443654 | 10.0 | uM | LJP6 | 72 | hr | 765 | 269 | 3124 | 0.0862 | -0.2101 |
| BT-20 | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 1334 | 278 | 3970 | 0.0702 | -0.4006 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1694 | 279 | 11155 | 0.0251 | -0.1495 |
| BT-20 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1334 | 285 | 3970 | 0.0719 | -0.3981 |
| MCF 10A | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 1694 | 289 | 11155 | 0.0260 | -0.1485 |
| Hs 578T | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 765 | 292 | 3124 | 0.0935 | -0.2005 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 1694 | 294 | 11155 | 0.0264 | -0.1480 |
| SK-BR-3 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 2543 | 295 | 5578 | 0.0529 | -0.7408 |
| BT-20 | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1334 | 295 | 3970 | 0.0744 | -0.3943 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1389 | 296 | 5667 | 0.0523 | -0.2553 |
| MCF7 | AZD 5438 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 297 | 5667 | 0.0524 | -0.2552 |