LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1476 | 861 | 3694 | 0.2332 | -0.2775 |
| MCF7 | Canertinib | 10.0 | uM | LJP6 | 72 | hr | 1235 | 430 | 4156 | 0.1035 | -0.2756 |
| SK-BR-3 | Dasatinib | 10.0 | uM | LJP6 | 72 | hr | 1476 | 881 | 3694 | 0.2386 | -0.2685 |
| SK-BR-3 | SNS-032 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 885 | 3694 | 0.2396 | -0.2669 |
| BT-20 | A443654 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 652 | 5505 | 0.1185 | -0.2613 |
| SK-BR-3 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 905 | 3694 | 0.2452 | -0.2575 |
| BT-20 | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 673 | 5505 | 0.1224 | -0.2557 |
| SK-BR-3 | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 918 | 3694 | 0.2485 | -0.2520 |
| SK-BR-3 | CGP60474 | 0.04 | uM | LJP6 | 72 | hr | 1476 | 922 | 3694 | 0.2496 | -0.2502 |
| MCF7 | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1235 | 512 | 4156 | 0.1233 | -0.2476 |
| SK-BR-3 | PHA-665752 | 10.0 | uM | LJP5 | 72 | hr | 1476 | 928 | 3694 | 0.2514 | -0.2472 |
| MCF7 | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 514 | 4156 | 0.1238 | -0.2468 |
| SK-BR-3 | QL-XII-47 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 931 | 3694 | 0.2520 | -0.2461 |
| MCF7 | Geldanamycin | 10.0 | uM | LJP5 | 72 | hr | 1235 | 525 | 4156 | 0.1265 | -0.2430 |
| SK-BR-3 | Withaferin A | 10.0 | uM | LJP5 | 72 | hr | 1476 | 940 | 3694 | 0.2546 | -0.2419 |
| MCF7 | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 542 | 4156 | 0.1305 | -0.2373 |
| MCF7 | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 551 | 4156 | 0.1326 | -0.2343 |
| MCF7 | Geldanamycin | 10.0 | uM | LJP6 | 72 | hr | 1235 | 552 | 4156 | 0.1330 | -0.2338 |
| SK-BR-3 | Celastrol | 3.33 | uM | LJP6 | 72 | hr | 1476 | 963 | 3694 | 0.2607 | -0.2317 |
| SK-BR-3 | NVP-TAE684 | 10.0 | uM | LJP6 | 72 | hr | 1476 | 965 | 3694 | 0.2613 | -0.2306 |
| BT-20 | GSK1059615 | 10.0 | uM | LJP5 | 72 | hr | 1657 | 772 | 5505 | 0.1403 | -0.2300 |
| MCF7 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 565 | 4156 | 0.1361 | -0.2293 |
| MCF7 | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 573 | 4156 | 0.1379 | -0.2268 |
| MCF7 | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 573 | 4156 | 0.1379 | -0.2268 |
| MCF7 | SNS-032 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 574 | 4156 | 0.1383 | -0.2262 |