PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 1 | hr | Total c-Jun | 2.37960 | -0.19138 |
| SKMEL28 | 1 | hr | p-cJun(S63) | 2.59170 | -0.03916 |
| SKMEL28 | 1 | hr | p-P38(T180/Y182) | 2.68550 | -0.86462 |
| SKMEL28 | 1 | hr | p-HSP27(S82) | 1.61810 | 3.06270 |
| SKMEL28 | 1 | hr | p-NFKB(S536) | 2.39670 | 0.78948 |
| SKMEL28 | 1 | hr | Bim | 1.22360 | 0.21613 |
| SKMEL28 | 1 | hr | cPARP | 1.70050 | 0.37833 |
| SKMEL28 | 1 | hr | p-Histone H3(S10) | 1.29550 | -0.37606 |
| SKMEL28 | 1 | hr | p27 Kip1 | 0.70026 | 0.89435 |
| SKMEL28 | 5 | hr | p-p90RSK(S380) | 0.75833 | 1.54040 |
| SKMEL28 | 5 | hr | p-p90RSK(T573) | -2.67620 | 1.78160 |
| SKMEL28 | 5 | hr | p-AKT(T308) | NaN | NaN |
| SKMEL28 | 5 | hr | p-AKT(S473) | -3.98020 | 1.49510 |
| SKMEL28 | 5 | hr | p-mTOR(S2448) | -2.12220 | 1.71270 |
| SKMEL28 | 5 | hr | p-p70S6K(T421/S424) | -1.51080 | 2.64720 |
| SKMEL28 | 5 | hr | p-p70S6K(T389) | -0.11702 | 1.06870 |
| SKMEL28 | 5 | hr | p-S6(S235/236) | 1.84450 | 0.09213 |
| SKMEL28 | 5 | hr | p-AMPK(T172) | -2.58670 | 1.85850 |
| SKMEL28 | 5 | hr | p-JNK(T183/Y185) | -1.04360 | 0.08248 |
| SKMEL28 | 5 | hr | Total c-Jun | 1.11600 | 1.23180 |
| SKMEL28 | 5 | hr | p-cJun(S63) | -2.56550 | 2.34190 |
| SKMEL28 | 5 | hr | p-P38(T180/Y182) | -2.44440 | 0.77193 |
| SKMEL28 | 5 | hr | p-HSP27(S82) | -2.95120 | 3.05280 |
| SKMEL28 | 5 | hr | p-NFKB(S536) | -1.43730 | 3.28840 |
| SKMEL28 | 5 | hr | Bim | -3.25850 | 1.63820 |