Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 210.57 | p-Rb(S807/S811) | 110.35 | p-S6(S235/S236 | 439.65 | 2 | WM1552C-signal2 | G10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 277.62 | p-Rb(S807/S811) | 113.74 | p-S6(S235/S236 | 415.75 | 2 | WM1552C-signal2 | G11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 199.56 | p-Rb(S807/S811) | 57.27 | p-S6(S235/S236 | 29.25 | 2 | WM1552C-signal2 | G2 |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 146.05 | p-Rb(S807/S811) | 52.87 | p-S6(S235/S236 | 247.44 | 2 | WM1552C-signal2 | G3 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 177.34 | p-Rb(S807/S811) | 61.94 | p-S6(S235/S236 | 398.32 | 2 | WM1552C-signal2 | G4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 158.64 | p-Rb(S807/S811) | 76.31 | p-S6(S235/S236 | 405.08 | 2 | WM1552C-signal2 | G5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 232.69 | p-Rb(S807/S811) | 95.77 | p-S6(S235/S236 | 414.55 | 2 | WM1552C-signal2 | G6 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 191.70 | p-Rb(S807/S811) | 97.70 | p-S6(S235/S236 | 403.09 | 2 | WM1552C-signal2 | G7 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 197.88 | p-Rb(S807/S811) | 110.31 | p-S6(S235/S236 | 410.75 | 2 | WM1552C-signal2 | G8 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 215.02 | p-Rb(S807/S811) | 116.21 | p-S6(S235/S236 | 424.78 | 2 | WM1552C-signal2 | G9 |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | Ki-67 | 1556.10 | p-Rb(S807/S811) | 107.86 | p-cJun(S73) | 143.87 | 1 | WM1552C-signal3 | B10 | |
| Vemurafenib | WM1552C | 0.0000 | uM | 24 | hr | | Ki-67 | 1693.60 | p-Rb(S807/S811) | 110.42 | p-cJun(S73) | 138.63 | 1 | WM1552C-signal3 | B11 | |
| Vemurafenib | WM1552C | 5.0000 | uM | 24 | hr | | Ki-67 | 973.61 | p-Rb(S807/S811) | 47.01 | p-cJun(S73) | 59.51 | 1 | WM1552C-signal3 | B2 | |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 913.80 | p-Rb(S807/S811) | 42.09 | p-cJun(S73) | 98.86 | 1 | WM1552C-signal3 | B3 | |
| Vemurafenib | WM1552C | 0.8000 | uM | 24 | hr | | Ki-67 | 1044.70 | p-Rb(S807/S811) | 52.94 | p-cJun(S73) | 128.12 | 1 | WM1552C-signal3 | B4 | |
| Vemurafenib | WM1552C | 0.3200 | uM | 24 | hr | | Ki-67 | 1190.60 | p-Rb(S807/S811) | 70.53 | p-cJun(S73) | 155.05 | 1 | WM1552C-signal3 | B5 | |
| Vemurafenib | WM1552C | 0.1280 | uM | 24 | hr | | Ki-67 | 1391.60 | p-Rb(S807/S811) | 87.70 | p-cJun(S73) | 154.40 | 1 | WM1552C-signal3 | B6 | |
| Vemurafenib | WM1552C | 0.0512 | uM | 24 | hr | | Ki-67 | 1451.30 | p-Rb(S807/S811) | 98.22 | p-cJun(S73) | 157.24 | 1 | WM1552C-signal3 | B7 | |
| Vemurafenib | WM1552C | 0.0205 | uM | 24 | hr | | Ki-67 | 1588.20 | p-Rb(S807/S811) | 104.90 | p-cJun(S73) | 155.81 | 1 | WM1552C-signal3 | B8 | |
| Vemurafenib | WM1552C | 0.0082 | uM | 24 | hr | | Ki-67 | 1588.00 | p-Rb(S807/S811) | 105.77 | p-cJun(S73) | 146.98 | 1 | WM1552C-signal3 | B9 | |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | Ki-67 | 1609.30 | p-Rb(S807/S811) | 102.99 | p-cJun(S73) | 143.15 | 2 | WM1552C-signal3 | C10 | |
| Vemurafenib | WM1552C | 0.0000 | uM | 24 | hr | | Ki-67 | 1637.30 | p-Rb(S807/S811) | 105.15 | p-cJun(S73) | 139.30 | 2 | WM1552C-signal3 | C11 | |
| Vemurafenib | WM1552C | 5.0000 | uM | 24 | hr | | Ki-67 | 955.89 | p-Rb(S807/S811) | 49.08 | p-cJun(S73) | 59.90 | 2 | WM1552C-signal3 | C2 | |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 885.89 | p-Rb(S807/S811) | 44.19 | p-cJun(S73) | 99.31 | 2 | WM1552C-signal3 | C3 | |
| Vemurafenib | WM1552C | 0.8000 | uM | 24 | hr | | Ki-67 | 1017.40 | p-Rb(S807/S811) | 54.97 | p-cJun(S73) | 137.70 | 2 | WM1552C-signal3 | C4 |