Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 257.65 | p-Rb(S807/S811) | 38.40 | p-ERK(T202/Y204) | 44.96 | 2 | WM115-signal1 | C5 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | p27 Kip1 | 235.53 | p-Rb(S807/S811) | 54.90 | p-ERK(T202/Y204) | 152.31 | 2 | WM115-signal1 | C6 | |
| Vemurafenib | WM-115 | 0.0512 | uM | 24 | hr | | p27 Kip1 | 238.56 | p-Rb(S807/S811) | 70.44 | p-ERK(T202/Y204) | 385.55 | 2 | WM115-signal1 | C7 | |
| Vemurafenib | WM-115 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 230.38 | p-Rb(S807/S811) | 73.32 | p-ERK(T202/Y204) | 501.50 | 2 | WM115-signal1 | C8 | |
| Vemurafenib | WM-115 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 224.35 | p-Rb(S807/S811) | 70.42 | p-ERK(T202/Y204) | 575.35 | 2 | WM115-signal1 | C9 | |
| JNK-IN-8 | WM-115 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 227.05 | p-Rb(S807/S811) | 74.53 | p-ERK(T202/Y204) | 625.81 | 1 | WM115-signal1 | D10 | |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 238.03 | p-Rb(S807/S811) | 74.48 | p-ERK(T202/Y204) | 630.06 | 1 | WM115-signal1 | D11 | |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | p27 Kip1 | 230.19 | p-Rb(S807/S811) | 77.30 | p-ERK(T202/Y204) | 802.24 | 1 | WM115-signal1 | D2 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 254.69 | p-Rb(S807/S811) | 87.41 | p-ERK(T202/Y204) | 724.06 | 1 | WM115-signal1 | D3 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 243.86 | p-Rb(S807/S811) | 88.86 | p-ERK(T202/Y204) | 663.72 | 1 | WM115-signal1 | D4 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 236.84 | p-Rb(S807/S811) | 83.75 | p-ERK(T202/Y204) | 640.13 | 1 | WM115-signal1 | D5 | |
| JNK-IN-8 | WM-115 | 0.1280 | uM | 24 | hr | | p27 Kip1 | 250.36 | p-Rb(S807/S811) | 85.23 | p-ERK(T202/Y204) | 658.54 | 1 | WM115-signal1 | D6 | |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | p27 Kip1 | 242.63 | p-Rb(S807/S811) | 82.99 | p-ERK(T202/Y204) | 649.81 | 1 | WM115-signal1 | D7 | |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 235.89 | p-Rb(S807/S811) | 78.16 | p-ERK(T202/Y204) | 655.44 | 1 | WM115-signal1 | D8 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 223.47 | p-Rb(S807/S811) | 74.36 | p-ERK(T202/Y204) | 609.12 | 1 | WM115-signal1 | D9 | |
| JNK-IN-8 | WM-115 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 222.05 | p-Rb(S807/S811) | 76.04 | p-ERK(T202/Y204) | 636.67 | 2 | WM115-signal1 | E10 | |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 225.01 | p-Rb(S807/S811) | 72.59 | p-ERK(T202/Y204) | 628.25 | 2 | WM115-signal1 | E11 | |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | p27 Kip1 | 267.33 | p-Rb(S807/S811) | 79.84 | p-ERK(T202/Y204) | 786.46 | 2 | WM115-signal1 | E2 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 250.02 | p-Rb(S807/S811) | 88.53 | p-ERK(T202/Y204) | 714.03 | 2 | WM115-signal1 | E3 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 235.37 | p-Rb(S807/S811) | 88.77 | p-ERK(T202/Y204) | 657.24 | 2 | WM115-signal1 | E4 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 232.47 | p-Rb(S807/S811) | 84.23 | p-ERK(T202/Y204) | 633.23 | 2 | WM115-signal1 | E5 | |
| JNK-IN-8 | WM-115 | 0.1280 | uM | 24 | hr | | p27 Kip1 | 235.79 | p-Rb(S807/S811) | 81.08 | p-ERK(T202/Y204) | 651.65 | 2 | WM115-signal1 | E6 | |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | p27 Kip1 | 237.86 | p-Rb(S807/S811) | 81.40 | p-ERK(T202/Y204) | 668.60 | 2 | WM115-signal1 | E7 | |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 228.02 | p-Rb(S807/S811) | 77.98 | p-ERK(T202/Y204) | 657.81 | 2 | WM115-signal1 | E8 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 226.04 | p-Rb(S807/S811) | 77.90 | p-ERK(T202/Y204) | 670.95 | 2 | WM115-signal1 | E9 |