Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset - HMS LINCS Database

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)

August 25, 2015: The data file for this dataset was updated to include additional DMSO control data that were inadvertently omitted from the original version. The Assay Protocol description of how experimental data were normalized to DMSO control data also was clarified (point 9).

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Small Molecule	Cell Line	Drug Concentration	Conc Unit	Time Point	Time Point Unit	Replicate	Scanner/Software	pMEK(S217/221)	Normalized Median pMEK(S217/221)	pERK(T202/Y204)	Normalized Median pERK(T202/Y204)	p-p90RSK(S380)	Normalized Median p-p90RSK(S380)	p-p90RSK(T573)	Normalized Median p-p90RSK(T573)	p-AKT(T308)	p-AKT(S473)	Normalized Median p-AKT(S473)	p-mTOR(S2448)	Normalized Median p-mTOR(S2448)	p-p70S6K(T421/S424)	Normalized Median p-p70S6K(T421/S424)	p-p70S6K(T389)	Normalized Median p-p70S6K(T389)	p-S6(S235/236)	Normalized Median p-S6(S235/236)	p-AMPK(T172)	Normalized Median p-AMPK(T172)	p-JNK(T183/Y185)	Normalized Median p-JNK(T183/Y185)	Total c-Jun	Normalized Median Total c-Jun	p-cJun(S63)	Normalized Median p-cJun(S63)	p-P38(T180/Y182)	Normalized Median p-P38(T180/Y182)	p-HSP27(S82)	Normalized Median p-HSP27(S82)	p-NFKB(S536)	Normalized Median p-NFKB(S536)	Bim	Normalized Median Bim	cPARP	Normalized Median cPARP	p-Histone H3(S10)	Normalized Median p-Histone H3(S10)	p27 Kip1	Normalized Median p27 Kip1
	LOXIMVI	0.0000	uM	48	hr	6	Odyssey/Microvigene	0.3953		0.9709				0.2198		0.2793	0.2370		0.4184				0.2710		0.5405		0.4149		0.4405		0.7576		0.3390		0.4386						0.1385		0.2310		0.8929		0.4149
	LOXIMVI	0.0000	uM	48	hr	6	Odyssey/Microvigene	0.4167		0.9709				0.2404		0.2933	0.2611		0.4202				0.2604		0.5682		0.4444		0.4673		0.7634		0.3226		0.4673						0.1443		0.2364		0.8621		0.4167
	LOXIMVI	0.0000	uM	48	hr	6	Odyssey/Microvigene	0.3677		0.9009				0.2151		0.3115	0.2347		0.4049				0.2577		0.5587		0.3759		0.4444		0.7463		0.3247		0.4505						0.1344		0.2494		0.8772		0.4049
	LOXIMVI	0.0000	uM	48	hr	6	Odyssey/Microvigene	0.4386		0.9434				0.2584		0.3333	0.2604		0.4149				0.2618		0.5780		0.3704		0.4566		0.7752		0.3311		0.4348						0.1490		0.2538		0.9615		0.4167
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.3861		0.9346				0.2410		0.2907	0.2747		0.3861				0.2469		0.5155		0.3497		0.4464		0.7194		0.3356		0.4329						0.1522		0.2571		0.8696		0.4525
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.4237		0.9174				0.2494		0.2857	0.2865		0.4049				0.2481		0.4951		0.3509		0.4566		0.7194		0.3247		0.4464						0.1337		0.2725		0.8333		0.4505
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.4132		0.8929				0.2695		0.2941	0.2667		0.3937				0.2604		0.5208		0.3356		0.4566		0.7246		0.3300		0.4525						0.1431		0.2717		0.8333		0.4405
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.4255		0.8929				0.2611		0.2865	0.3003		0.3968						0.5465		0.3425		0.4184		0.7246		0.3236		0.4505						0.1458		0.2584		0.8696		0.4630
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.3984		0.9615				0.2247		0.2755	0.2445		0.4032				0.2525		0.5435		0.3663		0.4464		0.6897		0.3215		0.4386						0.1247		0.2494		0.9091		0.4082
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.3876		0.9259				0.2688		0.2653	0.2469		0.4082				0.2597		0.5208		0.3623		0.3984		0.6993		0.3106		0.4405						0.1307		0.2304		0.9174		0.4065
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.3968		0.9259				0.2165		0.2985	0.2336		0.4000				0.2525		0.5587		0.3472		0.4310		0.6536		0.3030		0.4484						0.1357		0.2618		0.8265		0.4149
	LOXIMVI	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.4115		0.8772				0.2725		0.2985	0.2667		0.4065				0.2591		0.5525		0.3497		0.3876		0.6897		0.3106								0.1425		0.2525		0.8333		0.4237
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.4386		0.9346				0.2551		0.3268	0.2976		0.3831				0.2703		0.5263		0.3311		0.4651		0.6993		0.3333		0.4673						0.1577		0.2874		0.7937		0.4717
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.4695		0.9009				0.2457		0.3401	0.3145		0.3984				0.2770		0.5348		0.3247		0.4348		0.6897		0.3333		0.4608						0.1443		0.2762		0.8130		0.4587
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.4717		0.8850				0.2445		0.3817	0.3165		0.4115				0.3155		0.6024		0.3257		0.4695		0.7353		0.3610		0.5000						0.1435		0.3247		0.7752		0.4878
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.5000		0.9009						0.3718	0.3460		0.4292				0.3257		0.6289		0.3333		0.4405		0.7299		0.3571		0.4902						0.1647		0.3049		0.7692		0.5263
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.4484		0.9804				0.2370		0.2985	0.2732		0.4000				0.2817		0.5618		0.3610		0.4630		0.6897		0.3311		0.4808						0.1431		0.2825		0.8547		0.4444
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.4292		0.9615				0.2591		0.2907	0.2882		0.4082				0.2916		0.5780		0.3677		0.4274		0.6849		0.3460		0.4367						0.1399		0.2519		0.8475		0.4464
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.5181		0.8772				0.2208		0.3906	0.2865		0.3968				0.2924		0.5988		0.3559		0.4739		0.6993		0.3333		0.4878						0.1253		0.2907		0.7937		0.4310
	LOXIMVI	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.4854		0.8696				0.2451		0.3774	0.3030		0.4237				0.2967		0.6211		0.3690		0.4329		0.7042		0.3155		0.4505						0.1250		0.2584		0.7874		0.4651
SB590885	MMAC-SF	0.0032	uM	1	hr	1	InnoScan/Mapix	0.1066	0.5169	1.0526	0.5567	0.0079	0.9345	0.0163	0.9861		0.0238	0.6792	0.1508	1.0288	0.1637	1.0470	0.0509	1.0298	0.5495	0.3919	0.0828	1.0107	0.0667	0.9976	0.0436	0.4931	0.0355	1.1311	0.0458	1.0932	0.0139	1.1517	0.1927	0.6912	0.0629	1.4957	0.0113	0.9459	0.0939	0.4987	0.3021	0.8603
SB590885	MMAC-SF	0.0032	uM	1	hr	2	InnoScan/Mapix	0.1131	0.5169	1.0638	0.5567	0.0103	0.9345	0.0127	0.9861		0.0248	0.6792	0.1637	1.0288	0.1715	1.0470	0.0545	1.0298	0.9174	0.3919	0.0808	1.0107	0.0687	0.9976	0.0525	0.4931	0.0271	1.1311	0.0586	1.0932	0.0108	1.1517	0.2075	0.6912	0.0676	1.4957	0.0139	0.9459	0.1130	0.4987	0.3096	0.8603
SB590885	MMAC-SF	0.0032	uM	1	hr	3	InnoScan/Mapix	0.0637	0.5169	0.8000	0.5567	0.0092	0.9345	0.0261	0.9861		0.0288	0.6792	0.1623	1.0288	0.2183	1.0470	0.0491	1.0298	0.5465	0.3919	0.0813	1.0107	0.0904	0.9976	0.0495	0.4931	0.0281	1.1311	0.0524	1.0932		1.1517		0.6912	0.1004	1.4957	0.0179	0.9459	0.1209	0.4987	0.3759	0.8603
SB590885	MMAC-SF	0.0032	uM	1	hr	4	InnoScan/Mapix	0.1078	0.5169	1.2048	0.5567	0.0097	0.9345	0.0095	0.9861		0.0287	0.6792	0.1678	1.0288	0.1818	1.0470	0.0474	1.0298	0.6369	0.3919	0.0873	1.0107	0.0771	0.9976	0.0504	0.4931	0.0382	1.1311	0.0553	1.0932	0.0089	1.1517	0.1890	0.6912	0.0745	1.4957	0.0125	0.9459	0.1139	0.4987	0.3145	0.8603
SB590885	MMAC-SF	0.0032	uM	1	hr	5	InnoScan/Mapix	0.1099	0.5169	1.1364	0.5567	0.0131	0.9345	0.0100	0.9861		0.0283	0.6792	0.1658	1.0288	0.1656	1.0470	0.0554	1.0298	0.6135	0.3919	0.0847	1.0107	0.0818	0.9976	0.0569	0.4931	0.0417	1.1311	0.0519	1.0932	0.0124	1.1517	0.2004	0.6912	0.0808	1.4957	0.0299	0.9459	0.1423	0.4987	0.2740	0.8603

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HMS LINCS Project

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)