Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset - HMS LINCS Database

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)

August 25, 2015: The data file for this dataset was updated to include additional DMSO control data that were inadvertently omitted from the original version. The Assay Protocol description of how experimental data were normalized to DMSO control data also was clarified (point 9).

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Small Molecule	Cell Line	Drug Concentration	Conc Unit	Time Point	Time Point Unit	Replicate	Scanner/Software	pMEK(S217/221)	Normalized Median pMEK(S217/221)	pERK(T202/Y204)	Normalized Median pERK(T202/Y204)	p-p90RSK(S380)	p-p90RSK(T573)	Normalized Median p-p90RSK(T573)	p-AKT(T308)	Normalized Median p-AKT(T308)	p-AKT(S473)	Normalized Median p-AKT(S473)	p-mTOR(S2448)	Normalized Median p-mTOR(S2448)	p-p70S6K(T421/S424)	p-p70S6K(T389)	Normalized Median p-p70S6K(T389)	p-S6(S235/236)	Normalized Median p-S6(S235/236)	p-AMPK(T172)	Normalized Median p-AMPK(T172)	p-JNK(T183/Y185)	Normalized Median p-JNK(T183/Y185)	Total c-Jun	Normalized Median Total c-Jun	p-cJun(S63)	Normalized Median p-cJun(S63)	p-P38(T180/Y182)	Normalized Median p-P38(T180/Y182)	p-HSP27(S82)	p-NFKB(S536)	Bim	Normalized Median Bim	cPARP	Normalized Median cPARP	p-Histone H3(S10)	Normalized Median p-Histone H3(S10)	p27 Kip1	Normalized Median p27 Kip1
Vemurafenib	LOXIMVI	3.1600	uM	48	hr	4	Odyssey/Microvigene	0.1751	-1.2447	0.6757	-0.7485		0.2469	-0.2074	0.2500	-0.1343	0.2488	-0.0142	0.4274	-0.0359		0.2703	-0.2345	0.7353	-0.7763	0.3788	-0.0027	0.4444	-0.0283	0.8130	-0.3169	0.3021	-0.4032	0.3650	-0.4826			0.1667	0.3396	0.2519	0.0258	0.9709	-0.1853	0.4292	0.4182
Vemurafenib	LOXIMVI	3.1600	uM	48	hr	5	Odyssey/Microvigene	0.1618	-1.2447	0.6849	-0.7485		0.2299	-0.2074	0.2451	-0.1343	0.2160	-0.0142	0.4202	-0.0359		0.3068	-0.2345	0.7813	-0.7763	0.3690	-0.0027	0.4329	-0.0283	0.8130	-0.3169	0.3125	-0.4032	0.3290	-0.4826			0.1686	0.3396	0.2294	0.0258	0.9174	-0.1853	0.4505	0.4182
Vemurafenib	LOXIMVI	3.1600	uM	48	hr	6	Odyssey/Microvigene		-1.2447	0.6897	-0.7485		0.2179	-0.2074	0.2494	-0.1343	0.2132	-0.0142	0.4115	-0.0359		0.2618	-0.2345	0.7752	-0.7763	0.3390	-0.0027	0.4255	-0.0283	0.8130	-0.3169	0.3125	-0.4032	0.3718	-0.4826			0.1364	0.3396	0.2416	0.0258	0.8403	-0.1853	0.4386	0.4182
Vemurafenib	LOXIMVI	3.1600	uM	48	hr	7	Odyssey/Microvigene	0.1585	-1.2447	0.6803	-0.7485		0.2058	-0.2074	0.2506	-0.1343	0.1905	-0.0142	0.4016	-0.0359		0.2959	-0.2345	0.7634	-0.7763	0.3663	-0.0027	0.4274	-0.0283	0.7576	-0.3169	0.3086	-0.4032	0.3333	-0.4826			0.1650	0.3396	0.2370	0.0258	0.9434	-0.1853	0.4049	0.4182
Vemurafenib	LOXIMVI	3.1600	uM	48	hr	8	Odyssey/Microvigene	0.1704	-1.2447		-0.7485		0.1949	-0.2074	0.2392	-0.1343	0.2092	-0.0142	0.4082	-0.0359		0.2653	-0.2345	0.7634	-0.7763	0.3677	-0.0027	0.4292	-0.0283	0.7576	-0.3169	0.2882	-0.4032	0.3322	-0.4826			0.1383	0.3396	0.2053	0.0258	0.9174	-0.1853	0.4098	0.4182
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.1142		0.5952		0.0813	0.0134				0.0194		0.0482		0.0069	0.0122		0.6452		0.0316		0.0810		0.4717		0.0540		0.0515		0.0075	0.0601	0.0319		0.0174		0.1852		0.2703
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.1212		0.5814		0.0861	0.0155				0.0219		0.0520		0.0099	0.0132		0.7194		0.0383		0.0861		0.4329		0.0532		0.0577		0.0095	0.0654	0.0319		0.0152		0.1560		0.1815
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.0810		0.2717		0.0464	0.0090				0.0121		0.0300		0.0031	0.0045		0.5076		0.0163		0.0403		0.2732		0.0286		0.0281		0.0050	0.0459	0.0126		0.0096		0.0937		0.1362
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.0696		0.2451		0.0511	0.0092				0.0130		0.0278		0.0036	0.0059		0.4878		0.0179		0.0401		0.2899		0.0314		0.0242		0.0057	0.0431	0.0145		0.0084		0.0853		0.1014
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.1067		0.5988		0.0870					0.0188		0.0452		0.0054	0.0082		0.6667		0.0270		0.0776		0.4065		0.0471		0.0484		0.0071	0.0552	0.0299		0.0135		0.1443		0.2519
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.1030		0.5587		0.1007	0.0152				0.0196		0.0408		0.0064	0.0103		0.7634		0.0303		0.0796		0.3876		0.0453		0.0447		0.0086	0.0557	0.0268		0.0134		0.1199		0.1818
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.0816		0.3135		0.0470	0.0108				0.0125		0.0317		0.0034	0.0043		0.5208		0.0155		0.0444		0.2725		0.0339		0.0238		0.0042	0.0494	0.0102		0.0097		0.0948		0.1988
	LOXIMVI	0.0000	uM	1	hr	1	InnoScan/Mapix	0.0701		0.2681		0.0471	0.0106				0.0133		0.0285		0.0044	0.0054		0.4329		0.0145		0.0377		0.2950		0.0301		0.0252		0.0069	0.0496	0.0217		0.0111		0.0929		0.1776
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.1195		0.8547		0.0960	0.0157				0.0260		0.0717		0.0101	0.0146		0.6579		0.0458		0.1087		0.6024		0.0824		0.0665		0.0078	0.0801	0.0397		0.0261		0.2375		0.2227
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.1226		0.7937		0.1078	0.0178				0.0243		0.0547		0.0109	0.0157		0.7092		0.0475		0.1062		0.5618		0.0766		0.0746		0.0090	0.0881	0.0324		0.0175		0.1887		0.1842
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.0717		0.4237		0.0614	0.0115				0.0148		0.0334		0.0041	0.0060		0.5263		0.0216		0.0566		0.3356		0.0355		0.0324		0.0062	0.0476	0.0154		0.0123		0.1333		0.1191
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.0713		0.4000		0.0697	0.0144				0.0174		0.0313		0.0063	0.0086		0.4975		0.0243		0.0635		0.3165		0.0362		0.0319		0.0076	0.0495	0.0206		0.0109		0.1110		0.1285
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.0935		0.8850		0.1065	0.0160				0.0264		0.0540		0.0072	0.0114		0.6024		0.0351		0.0976		0.4951		0.0542		0.0633		0.0091	0.0617	0.0298		0.0210		0.1957		0.2359
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.0977		0.7937		0.1066	0.0228				0.0246		0.0532		0.0096	0.0147		0.6494		0.0328		0.1015		0.4630		0.0549		0.0611		0.0099	0.0730	0.0322		0.0151		0.1499		0.2336
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.0620		0.3236		0.0414	0.0083				0.0132		0.0274		0.0032	0.0042		0.4049		0.0139		0.0362		0.2398		0.0390		0.0238		0.0038	0.0498	0.0095		0.0087		0.0803		0.1536
	LOXIMVI	0.0000	uM	1	hr	2	InnoScan/Mapix	0.0616		0.3175		0.0559	0.0112				0.0162		0.0318		0.0058	0.0102		0.3367		0.0163		0.0364		0.2506		0.0501		0.0373		0.0084	0.0722	0.0291		0.0088		0.0754		0.1600
	LOXIMVI	0.0000	uM	1	hr	3	InnoScan/Mapix	0.1122		0.8130		0.0991	0.0166				0.0305		0.0666		0.0099	0.0161		0.7353		0.0554		0.1103		0.6173		0.0719		0.0747		0.0076	0.0800	0.0473		0.0217		0.2646		0.2740
	LOXIMVI	0.0000	uM	1	hr	3	InnoScan/Mapix	0.1156		0.7813		0.0941	0.0167				0.0210		0.0587		0.0128	0.0175		0.6579		0.0467		0.1004		0.5376		0.0596		0.0779		0.0085	0.0835	0.0415		0.0194		0.2375		0.1585
	LOXIMVI	0.0000	uM	1	hr	3	InnoScan/Mapix	0.0657		0.3356		0.0497	0.0105				0.0164		0.0289		0.0038	0.0051		0.5291		0.0199		0.0518		0.2924		0.0287		0.0301		0.0047	0.0412	0.0139		0.0105		0.1081		0.1221
	LOXIMVI	0.0000	uM	1	hr	3	InnoScan/Mapix	0.0671		0.3333		0.0505	0.0115				0.0129		0.0257		0.0052	0.0067		0.3846		0.0212		0.0492		0.2725		0.0272		0.0343		0.0065	0.0426	0.0212		0.0096		0.1089		0.1024

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HMS LINCS Project

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)