Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset - HMS LINCS Database

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)

August 25, 2015: The data file for this dataset was updated to include additional DMSO control data that were inadvertently omitted from the original version. The Assay Protocol description of how experimental data were normalized to DMSO control data also was clarified (point 9).

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Small Molecule	Cell Line	Drug Concentration	Conc Unit	Time Point	Time Point Unit	Replicate	Scanner/Software	pMEK(S217/221)	Normalized Median pMEK(S217/221)	pERK(T202/Y204)	Normalized Median pERK(T202/Y204)	p-p90RSK(S380)	Normalized Median p-p90RSK(S380)	p-p90RSK(T573)	Normalized Median p-p90RSK(T573)	p-AKT(T308)	Normalized Median p-AKT(T308)	p-AKT(S473)	Normalized Median p-AKT(S473)	p-mTOR(S2448)	Normalized Median p-mTOR(S2448)	p-p70S6K(T421/S424)	Normalized Median p-p70S6K(T421/S424)	p-p70S6K(T389)	Normalized Median p-p70S6K(T389)	p-S6(S235/236)	Normalized Median p-S6(S235/236)	p-AMPK(T172)	Normalized Median p-AMPK(T172)	p-JNK(T183/Y185)	Normalized Median p-JNK(T183/Y185)	Total c-Jun	Normalized Median Total c-Jun	p-cJun(S63)	Normalized Median p-cJun(S63)	p-P38(T180/Y182)	Normalized Median p-P38(T180/Y182)	p-HSP27(S82)	Normalized Median p-HSP27(S82)	p-NFKB(S536)	Normalized Median p-NFKB(S536)	Bim	Normalized Median Bim	cPARP	Normalized Median cPARP	p-Histone H3(S10)	Normalized Median p-Histone H3(S10)	p27 Kip1	Normalized Median p27 Kip1
Selumetinib	WM1552C	1.0000	uM	24	hr	7	InnoScan/Mapix	0.0583	0.7964	0.0728	-1.9769	0.0838	0.6923	0.0427	0.7349	0.0300	1.8231	0.0118	0.5259	0.0068	0.6057	0.0164	1.0522	0.0116	0.8688	0.0557	0.9900	0.1131	1.3621	0.0409	0.5801	0.0650	0.0528	0.0298	0.8859	0.0098	0.7582	0.0095	0.7419	0.0080	0.3204	0.0386	1.8602	0.0092	0.5399	0.0289	-1.2070	0.0424	-0.6293
Selumetinib	WM1552C	1.0000	uM	24	hr	8	InnoScan/Mapix	0.0486	0.7964	0.0771	-1.9769	0.0705	0.6923	0.0452	0.7349	0.0263	1.8231	0.0130	0.5259	0.0055	0.6057	0.0088	1.0522	0.0069	0.8688	0.0690	0.9900	0.1120	1.3621	0.0341	0.5801	0.0853	0.0528	0.0311	0.8859	0.0084	0.7582	0.0095	0.7419	0.0070	0.3204	0.0290	1.8602	0.0096	0.5399	0.0331	-1.2070	0.0367	-0.6293
Selumetinib	WM1552C	1.0000	uM	48	hr	1	InnoScan/Mapix	0.0407	0.6012	0.0717	-2.0475	0.0528	0.0178	0.0345	0.3753	0.0151	0.2544	0.0196	0.9708	0.0044	0.0983	0.0083	0.4538	0.0073	0.3083	0.0459	0.5601	0.0780	0.5864	0.0304	0.1430	0.0747	-0.0499	0.0397	1.1391	0.0073	0.2588	0.0068	0.2522	0.0054	-0.4102	0.0204	1.2047	0.0071	0.1116	0.0135	-2.5269	0.0402	-0.5411
Selumetinib	WM1552C	1.0000	uM	48	hr	2	InnoScan/Mapix	0.0477	0.6012	0.0949	-2.0475	0.0633	0.0178	0.0412	0.3753	0.0175	0.2544	0.0230	0.9708	0.0047	0.0983	0.0049	0.4538	0.0081	0.3083	0.0537	0.5601	0.0978	0.5864	0.0326	0.1430	0.1075	-0.0499	0.0413	1.1391	0.0059	0.2588	0.0053	0.2522	0.0064	-0.4102	0.0288	1.2047	0.0066	0.1116	0.0179	-2.5269	0.0593	-0.5411
Selumetinib	WM1552C	1.0000	uM	48	hr	3	InnoScan/Mapix	0.0462	0.6012	0.0633	-2.0475	0.0530	0.0178	0.0340	0.3753	0.0107	0.2544	0.0170	0.9708	0.0058	0.0983	0.0109	0.4538	0.0107	0.3083	0.0373	0.5601	0.0726	0.5864	0.0291	0.1430	0.0614	-0.0499	0.0360	1.1391	0.0091	0.2588	0.0080	0.2522		-0.4102	0.0307	1.2047	0.0077	0.1116	0.0127	-2.5269	0.0432	-0.5411
Selumetinib	WM1552C	1.0000	uM	48	hr	4	InnoScan/Mapix	0.0350	0.6012	0.0673	-2.0475	0.0432	0.0178	0.0291	0.3753	0.0099	0.2544	0.0187	0.9708	0.0040	0.0983	0.0062	0.4538	0.0063	0.3083	0.0467	0.5601	0.0714	0.5864	0.0257	0.1430	0.0691	-0.0499	0.0340	1.1391	0.0067	0.2588	0.0066	0.2522	0.0049	-0.4102	0.0172	1.2047	0.0071	0.1116	0.0107	-2.5269	0.0338	-0.5411
Selumetinib	WM1552C	1.0000	uM	48	hr	5	InnoScan/Mapix	0.0404	0.6012	0.0917	-2.0475	0.0539	0.0178	0.0368	0.3753	0.0109	0.2544	0.0182	0.9708	0.0049	0.0983	0.0094	0.4538	0.0078	0.3083	0.0540	0.5601	0.0782	0.5864	0.0345	0.1430	0.0864	-0.0499	0.0468	1.1391	0.0087	0.2588	0.0080	0.2522	0.0063	-0.4102	0.0233	1.2047	0.0081	0.1116	0.0202	-2.5269	0.0433	-0.5411
Selumetinib	WM1552C	1.0000	uM	48	hr	6	InnoScan/Mapix	0.0516	0.6012	0.1307	-2.0475	0.0709	0.0178	0.0430	0.3753	0.0138	0.2544	0.0264	0.9708	0.0058	0.0983	0.0078	0.4538	0.0113	0.3083	0.0618	0.5601	0.1136	0.5864	0.0423	0.1430	0.1236	-0.0499	0.0492	1.1391	0.0096	0.2588	0.0070	0.2522	0.0049	-0.4102	0.0360	1.2047	0.0080	0.1116	0.0233	-2.5269		-0.5411
Selumetinib	WM1552C	1.0000	uM	48	hr	7	InnoScan/Mapix	0.0469	0.6012	0.0674	-2.0475	0.0492	0.0178	0.0294	0.3753	0.0081	0.2544	0.0137	0.9708	0.0049	0.0983	0.0082	0.4538	0.0077	0.3083	0.0392	0.5601	0.0532	0.5864	0.0270	0.1430	0.0655	-0.0499	0.0321	1.1391	0.0076	0.2588	0.0062	0.2522	0.0055	-0.4102	0.0232	1.2047	0.0069	0.1116	0.0118	-2.5269	0.0440	-0.5411
Selumetinib	WM1552C	1.0000	uM	48	hr	8	InnoScan/Mapix	0.0396	0.6012	0.0750	-2.0475	0.0413	0.0178	0.0290	0.3753	0.0082	0.2544	0.0166	0.9708	0.0042	0.0983	0.0058	0.4538	0.0055	0.3083	0.0514	0.5601	0.0604	0.5864	0.0263	0.1430	0.0767	-0.0499	0.0361	1.1391	0.0072	0.2588	0.0065	0.2522	0.0047	-0.4102	0.0174	1.2047	0.0072	0.1116	0.0116	-2.5269	0.0395	-0.5411
Selumetinib	WM1552C	3.1600	uM	1	hr	1	InnoScan/Mapix	0.0325	0.2281	0.0187	-4.1717	0.0808	0.3320	0.0361	0.3412	0.0137	0.5532	0.0235	1.2586	0.0064	0.5506	0.0101	0.6926	0.0132	0.6524	0.0307	0.0487	0.0747	0.6710	0.0399	0.4614	0.1030	0.4135	0.0224	0.3965	0.0095	0.4382	0.0084	0.2844	0.0095	0.4178	0.0156	0.6334	0.0091	0.2531	0.0471	-0.8655	0.0801	0.2156
Selumetinib	WM1552C	3.1600	uM	1	hr	2	InnoScan/Mapix	0.0456	0.2281	0.0281	-4.1717	0.0833	0.3320	0.0485	0.3412	0.0180	0.5532	0.0360	1.2586	0.0081	0.5506	0.0111	0.6926	0.0128	0.6524	0.0342	0.0487	0.0912	0.6710	0.0424	0.4614	0.1701	0.4135	0.0199	0.3965	0.0082	0.4382	0.0068	0.2844	0.0117	0.4178	0.0250	0.6334	0.0106	0.2531	0.0572	-0.8655	0.1274	0.2156
Selumetinib	WM1552C	3.1600	uM	1	hr	3	InnoScan/Mapix	0.0320	0.2281	0.0123	-4.1717	0.0649	0.3320	0.0281	0.3412	0.0112	0.5532	0.0175	1.2586	0.0069	0.5506	0.0091	0.6926	0.0101	0.6524	0.0368	0.0487	0.0472	0.6710	0.0292	0.4614	0.0589	0.4135	0.0248	0.3965	0.0087	0.4382	0.0065	0.2844	0.0086	0.4178	0.0151	0.6334	0.0068	0.2531	0.0265	-0.8655	0.0505	0.2156
Selumetinib	WM1552C	3.1600	uM	1	hr	4	InnoScan/Mapix	0.0264	0.2281	0.0095	-4.1717	0.0492	0.3320	0.0265	0.3412	0.0103	0.5532	0.0197	1.2586	0.0047	0.5506	0.0062	0.6926	0.0075	0.6524	0.0413	0.0487	0.0545	0.6710	0.0242	0.4614	0.0766	0.4135	0.0173	0.3965	0.0069	0.4382	0.0034	0.2844	0.0074	0.4178	0.0102	0.6334	0.0060	0.2531	0.0333	-0.8655	0.0657	0.2156
Selumetinib	WM1552C	3.1600	uM	1	hr	5	InnoScan/Mapix	0.0346	0.2281	0.0182	-4.1717	0.0654	0.3320	0.0353	0.3412	0.0168	0.5532	0.0229	1.2586	0.0062	0.5506	0.0099	0.6926	0.0096	0.6524	0.0348	0.0487	0.0964	0.6710	0.0405	0.4614	0.1206	0.4135	0.0270	0.3965	0.0099	0.4382	0.0090	0.2844	0.0108	0.4178	0.0162	0.6334	0.0089	0.2531	0.0588	-0.8655	0.0835	0.2156
Selumetinib	WM1552C	3.1600	uM	1	hr	6	InnoScan/Mapix	0.0512	0.2281	0.0360	-4.1717	0.0943	0.3320	0.0512	0.3412	0.0199	0.5532	0.0406	1.2586	0.0085	0.5506	0.0097	0.6926	0.0160	0.6524	0.0345	0.0487		0.6710	0.0501	0.4614	0.1880	0.4135	0.0286	0.3965	0.0101	0.4382	0.0096	0.2844	0.0150	0.4178		0.6334	0.0091	0.2531	0.0752	-0.8655	0.1387	0.2156
Selumetinib	WM1552C	3.1600	uM	1	hr	7	InnoScan/Mapix	0.0344	0.2281	0.0155	-4.1717	0.0661	0.3320	0.0298	0.3412	0.0129	0.5532	0.0203	1.2586	0.0068	0.5506	0.0088	0.6926	0.0092	0.6524	0.0298	0.0487	0.0798	0.6710	0.0345	0.4614	0.0833	0.4135	0.0202	0.3965	0.0076	0.4382	0.0069	0.2844	0.0096	0.4178	0.0176	0.6334	0.0070	0.2531	0.0324	-0.8655	0.0536	0.2156
Selumetinib	WM1552C	3.1600	uM	1	hr	8	InnoScan/Mapix	0.0314	0.2281	0.0102	-4.1717	0.0536	0.3320	0.0317	0.3412	0.0125	0.5532	0.0221	1.2586	0.0051	0.5506	0.0062	0.6926	0.0068	0.6524	0.0298	0.0487	0.0840	0.6710	0.0301	0.4614	0.1057	0.4135	0.0228	0.3965	0.0074	0.4382	0.0065	0.2844	0.0082	0.4178	0.0130	0.6334	0.0071	0.2531	0.0366	-0.8655	0.0665	0.2156
Selumetinib	WM1552C	3.1600	uM	5	hr	1	InnoScan/Mapix	0.0438	0.8147	0.0286	-3.4535	0.1053	0.9248	0.0568	1.1141	0.0197	1.5098	0.0157	0.7790	0.0084	0.8730	0.0151	1.1944	0.0137	1.3117	0.0434	0.5392	0.1104	1.0637	0.0622	1.1108	0.0770	-0.0072	0.0322	0.8923	0.0132	1.0935	0.0180	1.5287	0.0160	1.1790	0.0306	1.5507	0.0137	1.0211	0.1359	0.8294	0.0740	0.3297
Selumetinib	WM1552C	3.1600	uM	5	hr	2	InnoScan/Mapix	0.0642	0.8147	0.0437	-3.4535	0.1294	0.9248	0.0837	1.1141	0.0258	1.5098	0.0270	0.7790	0.0102	0.8730	0.0133	1.1944	0.0178	1.3117	0.0462	0.5392	0.1473	1.0637	0.0652	1.1108	0.1201	-0.0072	0.0371	0.8923	0.0121	1.0935	0.0164	1.5287	0.0202	1.1790	0.0405	1.5507	0.0160	1.0211	0.1645	0.8294	0.1134	0.3297
Selumetinib	WM1552C	3.1600	uM	5	hr	3	InnoScan/Mapix	0.0587	0.8147	0.0345	-3.4535	0.1164	0.9248	0.0542	1.1141	0.0286	1.5098	0.0209	0.7790	0.0060	0.8730		1.1944	0.0237	1.3117		0.5392	0.1035	1.0637	0.0735	1.1108	0.0657	-0.0072		0.8923	0.0188	1.0935	0.0199	1.5287	0.0234	1.1790	0.0343	1.5507	0.0159	1.0211	0.1153	0.8294	0.0790	0.3297
Selumetinib	WM1552C	3.1600	uM	5	hr	4	InnoScan/Mapix	0.0460	0.8147	0.0202	-3.4535	0.0882	0.9248	0.0593	1.1141	0.0217	1.5098	0.0166	0.7790	0.0078	0.8730	0.0121	1.1944	0.0141	1.3117	0.0491	0.5392	0.1060	1.0637	0.0528	1.1108	0.0687	-0.0072	0.0319	0.8923	0.0134	1.0935	0.0110	1.5287	0.0143	1.1790	0.0230	1.5507	0.0125	1.0211	0.1385	0.8294	0.0833	0.3297
Selumetinib	WM1552C	3.1600	uM	5	hr	5	InnoScan/Mapix	0.0428	0.8147	0.0206	-3.4535	0.0935	0.9248	0.0539	1.1141	0.0312	1.5098	0.0156	0.7790	0.0080	0.8730	0.0125	1.1944	0.0128	1.3117	0.0483	0.5392	0.0912	1.0637	0.0540	1.1108	0.0796	-0.0072	0.0301	0.8923	0.0127	1.0935	0.0161	1.5287	0.0147	1.1790	0.0220	1.5507	0.0127	1.0211	0.1330	0.8294	0.0827	0.3297
Selumetinib	WM1552C	3.1600	uM	5	hr	6	InnoScan/Mapix	0.0666	0.8147	0.0397	-3.4535	0.1248	0.9248	0.0813	1.1141		1.5098	0.0276	0.7790	0.0117	0.8730	0.0141	1.1944	0.0214	1.3117	0.0499	0.5392	0.1423	1.0637	0.0651	1.1108	0.1242	-0.0072	0.0315	0.8923	0.0141	1.0935	0.0170	1.5287	0.0207	1.1790	0.0435	1.5507	0.0135	1.0211	0.1623	0.8294		0.3297
Selumetinib	WM1552C	3.1600	uM	5	hr	7	InnoScan/Mapix	0.0550	0.8147	0.0268	-3.4535	0.0889	0.9248	0.0518	1.1141	0.0259	1.5098	0.0157	0.7790	0.0097	0.8730	0.0143	1.1944	0.0171	1.3117	0.0544	0.5392	0.0912	1.0637	0.0545	1.1108	0.0675	-0.0072	0.0323	0.8923	0.0173	1.0935	0.0150	1.5287	0.0165	1.1790	0.0285	1.5507	0.0134	1.0211	0.1147	0.8294	0.0666	0.3297

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HMS LINCS Project

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)