Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)
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Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Replicate | Scanner/Software | pMEK(S217/221) | Normalized Median pMEK(S217/221) | pERK(T202/Y204) | Normalized Median pERK(T202/Y204) | p-p90RSK(S380) | Normalized Median p-p90RSK(S380) | p-p90RSK(T573) | Normalized Median p-p90RSK(T573) | p-AKT(T308) | Normalized Median p-AKT(T308) | p-AKT(S473) | Normalized Median p-AKT(S473) | p-mTOR(S2448) | Normalized Median p-mTOR(S2448) | p-p70S6K(T421/S424) | Normalized Median p-p70S6K(T421/S424) | p-p70S6K(T389) | Normalized Median p-p70S6K(T389) | p-S6(S235/236) | Normalized Median p-S6(S235/236) | p-AMPK(T172) | Normalized Median p-AMPK(T172) | p-JNK(T183/Y185) | Normalized Median p-JNK(T183/Y185) | Total c-Jun | Normalized Median Total c-Jun | p-cJun(S63) | Normalized Median p-cJun(S63) | p-P38(T180/Y182) | Normalized Median p-P38(T180/Y182) | p-HSP27(S82) | Normalized Median p-HSP27(S82) | p-NFKB(S536) | Normalized Median p-NFKB(S536) | Bim | Normalized Median Bim | cPARP | Normalized Median cPARP | p-Histone H3(S10) | Normalized Median p-Histone H3(S10) | p27 Kip1 | Normalized Median p27 Kip1 |
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SB590885 | C32 | 0.0032 | uM | 1 | hr | 1 | InnoScan/Mapix | 0.4525 | 0.2078 | 7.6923 | 0.1069 | 0.0485 | -0.2309 | 0.1490 | 0.2845 | 0.4926 | 0.2870 | 0.2049 | 0.0116 | 0.6711 | 0.1132 | 0.1825 | 0.4541 | 0.4673 | 0.4037 | 0.2137 | 0.2369 | 0.1592 | 0.3493 | 0.3290 | 0.3461 | 0.4587 | 0.4986 | 0.0894 | 0.1176 | 0.2994 | -0.6350 | 0.1431 | 0.2409 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 1 | hr | 2 | InnoScan/Mapix | 0.4546 | 0.2078 | 8.3333 | 0.1069 | 0.0532 | -0.2309 | 0.1282 | 0.2845 | 0.4386 | 0.2870 | 0.2304 | 0.0116 | 0.5495 | 0.1132 | 0.1715 | 0.4541 | 0.5291 | 0.4037 | 0.1961 | 0.2369 | 0.1650 | 0.3493 | 0.3509 | 0.3461 | 0.5208 | 0.4986 | 0.0962 | 0.1176 | 0.3030 | -0.6350 | 0.1395 | 0.2409 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 1 | hr | 3 | InnoScan/Mapix | 0.4630 | 0.2078 | 8.3333 | 0.1069 | 0.0573 | -0.2309 | 0.1272 | 0.2845 | 0.5000 | 0.2870 | 0.2513 | 0.0116 | 0.6024 | 0.1132 | 0.1684 | 0.4541 | 0.5025 | 0.4037 | 0.2123 | 0.2369 | 0.3493 | 0.3521 | 0.3461 | 0.4049 | 0.4986 | 0.0946 | 0.1176 | 0.2959 | -0.6350 | 0.1515 | 0.2409 | |||||||||||
SB590885 | C32 | 0.0032 | uM | 1 | hr | 4 | InnoScan/Mapix | 0.4673 | 0.2078 | 7.6923 | 0.1069 | 0.0833 | -0.2309 | 0.1412 | 0.2845 | 0.4673 | 0.2870 | 0.2427 | 0.0116 | 0.5525 | 0.1132 | 0.1692 | 0.4541 | 0.5102 | 0.4037 | 0.1976 | 0.2369 | 0.1543 | 0.3493 | 0.3597 | 0.3461 | 0.3984 | 0.4986 | 0.1148 | 0.1176 | 0.3115 | -0.6350 | 0.1527 | 0.2409 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 1 | hr | 5 | InnoScan/Mapix | 0.4717 | 0.2078 | 7.6923 | 0.1069 | 0.0472 | -0.2309 | 0.1410 | 0.2845 | 0.4505 | 0.2870 | 0.1912 | 0.0116 | 0.5376 | 0.1132 | 0.2004 | 0.4541 | 0.5952 | 0.4037 | 0.2364 | 0.2369 | 0.1590 | 0.3493 | 0.3521 | 0.3461 | 0.4587 | 0.4986 | 0.0840 | 0.1176 | 0.2976 | -0.6350 | 0.1919 | 0.2409 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 1 | hr | 6 | InnoScan/Mapix | 0.4717 | 0.2078 | 7.6923 | 0.1069 | 0.0524 | -0.2309 | 0.1629 | 0.2845 | 0.4237 | 0.2870 | 0.2315 | 0.0116 | 0.4808 | 0.1132 | 0.1883 | 0.4541 | 0.5556 | 0.4037 | 0.1992 | 0.2369 | 0.1658 | 0.3493 | 0.3597 | 0.3461 | 0.4630 | 0.4986 | 0.1107 | 0.1176 | 0.3115 | -0.6350 | 0.1621 | 0.2409 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 1 | hr | 7 | InnoScan/Mapix | 0.4926 | 0.2078 | 8.3333 | 0.1069 | 0.0521 | -0.2309 | 0.1548 | 0.2845 | 0.4274 | 0.2870 | 0.2096 | 0.0116 | 0.5155 | 0.1132 | 0.2132 | 0.4541 | 0.6329 | 0.4037 | 0.2310 | 0.2369 | 0.1675 | 0.3493 | 0.3534 | 0.3461 | 0.4986 | 0.0650 | 0.1176 | -0.6350 | 0.1577 | 0.2409 | ||||||||||||
SB590885 | C32 | 0.0032 | uM | 1 | hr | 8 | InnoScan/Mapix | 0.4902 | 0.2078 | 7.1429 | 0.1069 | 0.0842 | -0.2309 | 0.1580 | 0.2845 | 0.4167 | 0.2870 | 0.2227 | 0.0116 | 0.4831 | 0.1132 | 0.2058 | 0.4541 | 0.5917 | 0.4037 | 0.2101 | 0.2369 | 0.1835 | 0.3493 | 0.3257 | 0.3461 | 0.4630 | 0.4986 | 0.1114 | 0.1176 | 0.3040 | -0.6350 | 0.1848 | 0.2409 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 1 | InnoScan/Mapix | 0.4739 | 0.2701 | 6.2500 | 0.1069 | 0.0829 | 0.3457 | 0.0972 | 0.0970 | 0.3425 | 0.0079 | 0.2326 | 0.1613 | 0.6757 | 0.3238 | 0.1374 | 0.4610 | 0.3718 | 0.3088 | 0.1730 | 0.1875 | 0.3757 | 0.3623 | 0.4735 | 0.2611 | 0.1227 | 0.0767 | 0.3102 | 0.5076 | -0.0335 | 0.1311 | 0.2802 | |||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 2 | InnoScan/Mapix | 0.4717 | 0.2701 | 6.6667 | 0.1069 | 0.0709 | 0.3457 | 0.1019 | 0.0970 | 0.3106 | 0.0079 | 0.2639 | 0.1613 | 0.6250 | 0.3238 | 0.1359 | 0.4610 | 0.3922 | 0.3088 | 0.1883 | 0.1875 | 0.1499 | 0.3757 | 0.3584 | 0.4735 | 0.2941 | 0.1227 | 0.1170 | 0.3102 | 0.4566 | -0.0335 | 0.1490 | 0.2802 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 3 | InnoScan/Mapix | 0.5376 | 0.2701 | 8.3333 | 0.1069 | 0.1005 | 0.3457 | 0.1290 | 0.0970 | 0.4329 | 0.0079 | 0.2618 | 0.1613 | 0.6579 | 0.3238 | 0.2049 | 0.4610 | 0.5465 | 0.3088 | 0.2188 | 0.1875 | 0.1597 | 0.3757 | 0.3846 | 0.4735 | 0.3436 | 0.1227 | 0.1093 | 0.3102 | 0.5291 | -0.0335 | 0.1536 | 0.2802 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 4 | InnoScan/Mapix | 0.5128 | 0.2701 | 7.6923 | 0.1069 | 0.1074 | 0.3457 | 0.1475 | 0.0970 | 0.4098 | 0.0079 | 0.2924 | 0.1613 | 0.5917 | 0.3238 | 0.1972 | 0.4610 | 0.5128 | 0.3088 | 0.2028 | 0.1875 | 0.1832 | 0.3757 | 0.3831 | 0.4735 | 0.3268 | 0.1227 | 0.1127 | 0.3102 | 0.5435 | -0.0335 | 0.2310 | 0.2802 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 5 | InnoScan/Mapix | 0.4951 | 0.2701 | 7.6923 | 0.1069 | 0.0659 | 0.3457 | 0.1300 | 0.0970 | 0.3718 | 0.0079 | 0.2451 | 0.1613 | 0.6329 | 0.3238 | 0.1901 | 0.4610 | 0.5128 | 0.3088 | 0.2242 | 0.1875 | 0.1647 | 0.3757 | 0.4735 | 0.4386 | 0.1227 | 0.1236 | 0.3102 | 0.4630 | -0.0335 | 0.1307 | 0.2802 | |||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 6 | InnoScan/Mapix | 0.4739 | 0.2701 | 6.6667 | 0.1069 | 0.0749 | 0.3457 | 0.1258 | 0.0970 | 0.3472 | 0.0079 | 0.2469 | 0.1613 | 0.5682 | 0.3238 | 0.1792 | 0.4610 | 0.5025 | 0.3088 | 0.1942 | 0.1875 | 0.1698 | 0.3757 | 0.4167 | 0.4735 | 0.3636 | 0.1227 | 0.1080 | 0.3102 | 0.4525 | -0.0335 | 0.1656 | 0.2802 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 7 | InnoScan/Mapix | 0.4902 | 0.2701 | 8.3333 | 0.1069 | 0.0614 | 0.3457 | 0.1309 | 0.0970 | 0.3690 | 0.0079 | 0.2273 | 0.1613 | 0.6410 | 0.3238 | 0.1825 | 0.4610 | 0.5525 | 0.3088 | 0.2364 | 0.1875 | 0.1789 | 0.3757 | 0.4237 | 0.4735 | 0.3677 | 0.1227 | 0.0669 | 0.3102 | 0.4016 | -0.0335 | 0.2004 | 0.2802 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 5 | hr | 8 | InnoScan/Mapix | 0.4902 | 0.2701 | 7.6923 | 0.1069 | 0.0869 | 0.3457 | 0.1172 | 0.0970 | 0.3636 | 0.0079 | 0.2558 | 0.1613 | 0.5848 | 0.3238 | 0.2020 | 0.4610 | 0.5000 | 0.3088 | 0.2053 | 0.1875 | 0.1681 | 0.3757 | 0.3953 | 0.4735 | 0.4854 | 0.1227 | 0.1088 | 0.3102 | 0.4292 | -0.0335 | 0.1838 | 0.2802 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 1 | InnoScan/Mapix | 0.3953 | 0.0908 | 7.6923 | 0.1069 | 0.0730 | 0.5263 | 0.1405 | 0.2089 | 0.3546 | -0.0260 | 0.2242 | 0.2263 | 0.5988 | 0.2110 | 0.1880 | 0.2110 | 0.4831 | 0.3384 | 0.2183 | 0.3168 | 0.1285 | 0.1332 | 0.3195 | 0.1191 | 0.3731 | 0.1900 | 0.0679 | 0.0686 | 0.5747 | 0.3960 | 0.1221 | 0.2298 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 2 | InnoScan/Mapix | 0.4115 | 0.0908 | 8.3333 | 0.1069 | 0.0843 | 0.5263 | 0.1198 | 0.2089 | 0.3425 | -0.0260 | 0.2571 | 0.2263 | 0.5405 | 0.2110 | 0.1634 | 0.2110 | 0.5128 | 0.3384 | 0.2174 | 0.3168 | 0.1572 | 0.1332 | 0.3333 | 0.1191 | 0.3677 | 0.1900 | 0.0958 | 0.0686 | 0.5618 | 0.3960 | 0.1508 | 0.2298 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 3 | InnoScan/Mapix | 0.4425 | 0.0908 | 8.3333 | 0.1069 | 0.0883 | 0.5263 | 0.1297 | 0.2089 | 0.3610 | -0.0260 | 0.2688 | 0.2263 | 0.5650 | 0.2110 | 0.1550 | 0.2110 | 0.5465 | 0.3384 | 0.2304 | 0.3168 | 0.1401 | 0.1332 | 0.3236 | 0.1191 | 0.4219 | 0.1900 | 0.0888 | 0.0686 | 0.6098 | 0.3960 | 0.1412 | 0.2298 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 4 | InnoScan/Mapix | 0.4292 | 0.0908 | 7.6923 | 0.1069 | 0.1089 | 0.5263 | 0.1321 | 0.2089 | 0.3367 | -0.0260 | 0.2545 | 0.2263 | 0.5435 | 0.2110 | 0.1582 | 0.2110 | 0.5236 | 0.3384 | 0.2247 | 0.3168 | 0.1441 | 0.1332 | 0.3247 | 0.1191 | 0.3831 | 0.1900 | 0.1212 | 0.0686 | 0.6250 | 0.3960 | 0.1572 | 0.2298 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 5 | InnoScan/Mapix | 0.4425 | 0.0908 | 7.1429 | 0.1069 | 0.0903 | 0.5263 | 0.2024 | 0.2089 | 0.3663 | -0.0260 | 0.2571 | 0.2263 | 0.6993 | 0.2110 | 0.1235 | 0.2110 | 0.4608 | 0.3384 | 0.2268 | 0.3168 | 0.1244 | 0.1332 | 0.2833 | 0.1191 | 0.3215 | 0.1900 | 0.0805 | 0.0686 | 0.6803 | 0.3960 | 0.1502 | 0.2298 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 6 | InnoScan/Mapix | 0.4329 | 0.0908 | 6.2500 | 0.1069 | 0.0915 | 0.5263 | 0.2278 | 0.2089 | 0.3497 | -0.0260 | 0.2857 | 0.2263 | 0.6329 | 0.2110 | 0.1443 | 0.2110 | 0.4762 | 0.3384 | 0.2062 | 0.3168 | 0.1302 | 0.1332 | 0.2558 | 0.1191 | 0.2857 | 0.1900 | 0.0996 | 0.0686 | 0.6897 | 0.3960 | 0.1783 | 0.2298 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 7 | InnoScan/Mapix | 0.0908 | 7.6923 | 0.1069 | 0.0850 | 0.5263 | 0.1350 | 0.2089 | 0.3704 | -0.0260 | 0.2907 | 0.2263 | 0.6250 | 0.2110 | 0.1412 | 0.2110 | 0.5848 | 0.3384 | 0.2392 | 0.3168 | 0.1613 | 0.1332 | 0.2740 | 0.1191 | 0.3623 | 0.1900 | 0.0636 | 0.0686 | 0.6135 | 0.3960 | 0.1758 | 0.2298 | |||||||||||
SB590885 | C32 | 0.0032 | uM | 10 | hr | 8 | InnoScan/Mapix | 0.4587 | 0.0908 | 7.1429 | 0.1069 | 0.1116 | 0.5263 | 0.1511 | 0.2089 | 0.3690 | -0.0260 | 0.3021 | 0.2263 | 0.5236 | 0.2110 | 0.1664 | 0.2110 | 0.5465 | 0.3384 | 0.2217 | 0.3168 | 0.1560 | 0.1332 | 0.2674 | 0.1191 | 0.4608 | 0.1900 | 0.1143 | 0.0686 | 0.6410 | 0.3960 | 0.1916 | 0.2298 | ||||||||||
SB590885 | C32 | 0.0032 | uM | 24 | hr | 1 | InnoScan/Mapix | 0.3610 | -0.0602 | 6.2500 | -0.1461 | 0.0566 | 0.1788 | 0.1247 | 0.1061 | 0.4167 | 0.0894 | 0.2299 | 0.0766 | 0.4902 | -0.1316 | 0.1258 | -0.1054 | 0.3968 | 0.0542 | 0.1751 | 0.0000 | 0.1100 | 0.0226 | 0.1838 | -0.3528 | 0.3165 | -0.0370 | 0.0864 | 0.1510 | 0.3704 | -0.3455 | 0.1314 | 0.3657 |