Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PLX-4720 | C32 | 1.0000 | uM | 48 | hr | 1923 | 772 | 0.5601 | 0.4542 | 0.4015 | 0.4653 | 3 |
| PLX-4720 | C32 | 1.0000 | uM | 48 | hr | 1866 | 818 | 0.5099 | 0.4542 | 0.4384 | 0.4653 | 4 |
| PLX-4720 | C32 | 1.0000 | uM | 72 | hr | 937 | 599 | 0.1476 | 0.1817 | 0.6393 | 0.6192 | 1 |
| PLX-4720 | C32 | 1.0000 | uM | 72 | hr | 1088 | 688 | 0.1746 | 0.1817 | 0.6324 | 0.6192 | 2 |
| PLX-4720 | C32 | 1.0000 | uM | 72 | hr | 1109 | 685 | 0.1851 | 0.1817 | 0.6177 | 0.6192 | 3 |
| PLX-4720 | C32 | 1.0000 | uM | 72 | hr | 1219 | 716 | 0.2196 | 0.1817 | 0.5874 | 0.6192 | 4 |
| PLX-4720 | C32 | 3.1600 | uM | 24 | hr | 1770 | 516 | 0.7250 | 0.6928 | 0.2915 | 0.2905 | 1 |
| PLX-4720 | C32 | 3.1600 | uM | 24 | hr | 1777 | 592 | 0.6851 | 0.6928 | 0.3332 | 0.2905 | 2 |
| PLX-4720 | C32 | 3.1600 | uM | 24 | hr | 1520 | 387 | 0.6551 | 0.6928 | 0.2546 | 0.2905 | 3 |
| PLX-4720 | C32 | 3.1600 | uM | 24 | hr | 1702 | 481 | 0.7059 | 0.6928 | 0.2826 | 0.2905 | 4 |
| PLX-4720 | C32 | 3.1600 | uM | 48 | hr | 1504 | 1209 | 0.1435 | 0.1550 | 0.8039 | 0.7840 | 1 |
| PLX-4720 | C32 | 3.1600 | uM | 48 | hr | 1321 | 1073 | 0.1207 | 0.1550 | 0.8123 | 0.7840 | 2 |
| PLX-4720 | C32 | 3.1600 | uM | 48 | hr | 1443 | 1101 | 0.1664 | 0.1550 | 0.7630 | 0.7840 | 3 |
| PLX-4720 | C32 | 3.1600 | uM | 48 | hr | 1599 | 1210 | 0.1893 | 0.1550 | 0.7567 | 0.7840 | 4 |
| PLX-4720 | C32 | 3.1600 | uM | 72 | hr | 873 | 773 | 0.0437 | 0.0669 | 0.8855 | 0.8134 | 1 |
| PLX-4720 | C32 | 3.1600 | uM | 72 | hr | 820 | 631 | 0.0825 | 0.0669 | 0.7695 | 0.8134 | 2 |
| PLX-4720 | C32 | 3.1600 | uM | 72 | hr | 856 | 729 | 0.0554 | 0.0669 | 0.8516 | 0.8134 | 3 |
| PLX-4720 | C32 | 3.1600 | uM | 72 | hr | 778 | 581 | 0.0860 | 0.0669 | 0.7468 | 0.8134 | 4 |
| AZ-628 | C32 | 0.0032 | uM | 24 | hr | 2282 | 195 | 1.2066 | 1.0868 | 0.0855 | 0.0886 | 1 |
| AZ-628 | C32 | 0.0032 | uM | 24 | hr | 2319 | 203 | 1.2234 | 1.0868 | 0.0875 | 0.0886 | 2 |
| AZ-628 | C32 | 0.0032 | uM | 24 | hr | 1783 | 165 | 0.9355 | 1.0868 | 0.0925 | 0.0886 | 3 |
| AZ-628 | C32 | 0.0032 | uM | 24 | hr | 1864 | 166 | 0.9817 | 1.0868 | 0.0891 | 0.0886 | 4 |
| AZ-628 | C32 | 0.0032 | uM | 48 | hr | 2574 | 263 | 1.1245 | 1.1683 | 0.1022 | 0.0865 | 1 |
| AZ-628 | C32 | 0.0032 | uM | 48 | hr | 2432 | 229 | 1.0719 | 1.1683 | 0.0942 | 0.0865 | 2 |
| AZ-628 | C32 | 0.0032 | uM | 48 | hr | 2780 | 201 | 1.2549 | 1.1683 | 0.0723 | 0.0865 | 3 |