Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | RVH-421 | 1.0000 | uM | 48 | hr | 1414 | 100 | 0.6866 | 0.6582 | 0.0707 | 0.0671 | 2 |
| Selumetinib | RVH-421 | 1.0000 | uM | 48 | hr | 1344 | 65 | 0.6683 | 0.6582 | 0.0484 | 0.0671 | 3 |
| Selumetinib | RVH-421 | 1.0000 | uM | 48 | hr | 1337 | 94 | 0.6495 | 0.6582 | 0.0703 | 0.0671 | 4 |
| Selumetinib | RVH-421 | 1.0000 | uM | 72 | hr | 4863 | 318 | 0.5208 | 0.5114 | 0.0654 | 0.0599 | 1 |
| Selumetinib | RVH-421 | 1.0000 | uM | 72 | hr | 5305 | 292 | 0.5744 | 0.5114 | 0.0550 | 0.0599 | 2 |
| Selumetinib | RVH-421 | 1.0000 | uM | 72 | hr | 3944 | 229 | 0.4257 | 0.5114 | 0.0581 | 0.0599 | 3 |
| Selumetinib | RVH-421 | 1.0000 | uM | 72 | hr | 4877 | 298 | 0.5247 | 0.5114 | 0.0611 | 0.0599 | 4 |
| Selumetinib | RVH-421 | 3.1600 | uM | 24 | hr | 1256 | 76 | 0.8536 | 0.9195 | 0.0605 | 0.0612 | 1 |
| Selumetinib | RVH-421 | 3.1600 | uM | 24 | hr | 1452 | 90 | 0.9853 | 0.9195 | 0.0620 | 0.0612 | 2 |
| Selumetinib | RVH-421 | 3.1600 | uM | 24 | hr | 3 | ||||||
| Selumetinib | RVH-421 | 3.1600 | uM | 24 | hr | 4 | ||||||
| Selumetinib | RVH-421 | 3.1600 | uM | 48 | hr | 1241 | 113 | 0.5894 | 0.5932 | 0.0911 | 0.0755 | 1 |
| Selumetinib | RVH-421 | 3.1600 | uM | 48 | hr | 1230 | 104 | 0.5883 | 0.5932 | 0.0846 | 0.0755 | 2 |
| Selumetinib | RVH-421 | 3.1600 | uM | 48 | hr | 1228 | 70 | 0.6051 | 0.5932 | 0.0570 | 0.0755 | 3 |
| Selumetinib | RVH-421 | 3.1600 | uM | 48 | hr | 1213 | 84 | 0.5899 | 0.5932 | 0.0693 | 0.0755 | 4 |
| Selumetinib | RVH-421 | 3.1600 | uM | 72 | hr | 4522 | 523 | 0.4582 | 0.4879 | 0.1157 | 0.0977 | 1 |
| Selumetinib | RVH-421 | 3.1600 | uM | 72 | hr | 4854 | 456 | 0.5040 | 0.4879 | 0.0939 | 0.0977 | 2 |
| Selumetinib | RVH-421 | 3.1600 | uM | 72 | hr | 4379 | 445 | 0.4508 | 0.4879 | 0.1016 | 0.0977 | 3 |
| Selumetinib | RVH-421 | 3.1600 | uM | 72 | hr | 5107 | 407 | 0.5386 | 0.4879 | 0.0797 | 0.0977 | 4 |
| Vemurafenib | RVH-421 | 0.0032 | uM | 24 | hr | 1240 | 61 | 0.8529 | 0.8497 | 0.0492 | 0.0494 | 1 |
| Vemurafenib | RVH-421 | 0.0032 | uM | 24 | hr | 1231 | 61 | 0.8464 | 0.8497 | 0.0496 | 0.0494 | 2 |
| Vemurafenib | RVH-421 | 0.0032 | uM | 24 | hr | 3 | ||||||
| Vemurafenib | RVH-421 | 0.0032 | uM | 24 | hr | 4 | ||||||
| Vemurafenib | RVH-421 | 0.0032 | uM | 48 | hr | 2141 | 113 | 1.0596 | 1.0224 | 0.0528 | 0.0497 | 1 |
| Vemurafenib | RVH-421 | 0.0032 | uM | 48 | hr | 2386 | 126 | 1.1809 | 1.0224 | 0.0528 | 0.0497 | 2 |