HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
MK2206	AU565	10.0	nM	6	hr	183.97	46.00	p-Akt	14.47
MK2206	AU565	10.0	nM	24	hr	376.08	110.82	p-Akt	51.94
Triciribine	AU565	10.0	nM	6	hr	278.40	74.05	p-Akt	23.07
Triciribine	AU565	10.0	nM	24	hr	443.90	112.96	p-Akt	94.71
Dactolisib	AU565	10.0	nM	6	hr	210.20	46.30	p-Akt	19.17
Dactolisib	AU565	10.0	nM	24	hr	432.77	86.99	p-Akt	78.39
Gefitinib	HCC1954	10.0	nM	6	hr	169.47	33.97	p-Akt	21.97
Gefitinib	HCC1954	10.0	nM	24	hr	270.75	116.29	p-Akt	74.51
Torkinib	HCC1954	1.78	nM	6	hr	160.33	28.86	p-Akt	17.59
Torkinib	HCC1954	1.78	nM	24	hr	247.05	101.89	p-Akt	53.61
GSK1059615	HCC1954	10.0	nM	6	hr	303.36	83.16	p-Akt	39.46
GSK1059615	HCC1954	10.0	nM	24	hr	289.05	104.17	p-Akt	64.45
MK2206	HCC1954	10.0	nM	6	hr	210.41	69.32	p-Akt	24.32
MK2206	HCC1954	10.0	nM	24	hr	265.45	105.79	p-Akt	47.46
Triciribine	HCC1954	10.0	nM	6	hr	244.94	83.37	p-Akt	43.56
Triciribine	HCC1954	10.0	nM	24	hr	277.56	99.52	p-Akt	53.51
Dactolisib	HCC1954	10.0	nM	6	hr	191.42	72.50	p-Akt	29.37
Dactolisib	HCC1954	10.0	nM	24	hr	268.54	85.82	p-Akt	62.06
Gefitinib	MCF 10A	10.0	nM	6	hr	403.87	169.07	p-Akt	44.65
Gefitinib	MCF 10A	10.0	nM	24	hr	284.32	92.19	p-Akt	40.39
Torkinib	MCF 10A	1.78	nM	6	hr	418.98	157.03	p-Akt	41.14
Torkinib	MCF 10A	1.78	nM	24	hr	335.37	126.51	p-Akt	43.80
GSK1059615	MCF 10A	10.0	nM	6	hr	404.71	163.10	p-Akt	40.33
GSK1059615	MCF 10A	10.0	nM	24	hr	329.74	134.82	p-Akt	35.55
MK2206	MCF 10A	10.0	nM	6	hr	385.74	153.09	p-Akt	35.57

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