Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | MCF 10A | 10.0 | uM | 24 | hr | 311.22 | 119.59 | p-S6 | 356.95 | |
| Dactolisib | MCF 10A | 10.0 | uM | 6 | hr | 287.73 | 128.74 | p-S6 | 373.86 | |
| Dactolisib | MCF 10A | 10.0 | uM | 24 | hr | 431.99 | 70.22 | p-S6 | 271.08 | |
| Gefitinib | T47D | 10.0 | uM | 6 | hr | 165.90 | 109.45 | p-S6 | 483.50 | |
| Gefitinib | T47D | 10.0 | uM | 24 | hr | 140.88 | 93.13 | p-S6 | 272.88 | |
| Torkinib | T47D | 10.0 | uM | 6 | hr | 150.92 | 73.37 | p-S6 | 6.07 | |
| Torkinib | T47D | 10.0 | uM | 24 | hr | 146.76 | 43.93 | p-S6 | 6.94 | |
| GSK1059615 | T47D | 10.0 | uM | 6 | hr | 181.60 | 65.63 | p-S6 | 8.01 | |
| GSK1059615 | T47D | 10.0 | uM | 24 | hr | 202.49 | 68.59 | p-S6 | 9.26 | |
| MK2206 | T47D | 10.0 | uM | 6 | hr | 113.29 | 31.27 | p-S6 | 29.96 | |
| MK2206 | T47D | 10.0 | uM | 24 | hr | 183.08 | 52.93 | p-S6 | 33.32 | |
| Triciribine | T47D | 10.0 | uM | 6 | hr | 102.80 | 30.16 | p-S6 | 50.10 | |
| Triciribine | T47D | 10.0 | uM | 24 | hr | 195.69 | 74.52 | p-S6 | 435.43 | |
| Dactolisib | T47D | 10.0 | uM | 6 | hr | 85.91 | 37.58 | p-S6 | 3.98 | |
| Dactolisib | T47D | 10.0 | uM | 24 | hr | 142.42 | 100.03 | p-S6 | 6.69 | |
| Gefitinib | AU565 | 0 (control) | 6 | hr | 234.75 | 54.33 | p-Akt | 24.82 | | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 573.89 | 126.37 | p-Akt | 138.88 | | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 223.70 | 51.21 | p-Akt | 25.27 | | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 526.50 | 120.19 | p-Akt | 96.91 | | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 327.04 | 78.93 | p-Akt | 36.67 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 460.02 | 114.50 | p-Akt | 98.23 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 187.44 | 52.00 | p-Akt | 19.13 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 443.32 | 123.82 | p-Akt | 82.03 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 300.89 | 75.31 | p-Akt | 23.76 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 526.07 | 122.68 | p-Akt | 106.24 | |