Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AU565 | 10.0 | uM | 6 | hr | 343.83 | 80.65 | p-S6 | 72.27 | |
| Triciribine | AU565 | 10.0 | uM | 24 | hr | 446.15 | 70.49 | p-S6 | 113.45 | |
| Dactolisib | AU565 | 10.0 | uM | 6 | hr | 278.54 | 63.37 | p-S6 | 12.24 | |
| Dactolisib | AU565 | 10.0 | uM | 24 | hr | 465.12 | 65.11 | p-S6 | 11.59 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 211.07 | 86.26 | p-S6 | 324.68 | |
| Gefitinib | HCC1954 | 10.0 | uM | 24 | hr | 258.13 | 76.63 | p-S6 | 386.78 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 173.43 | 25.17 | p-S6 | 9.62 | |
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 237.78 | 57.82 | p-S6 | 7.72 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 445.73 | 78.86 | p-S6 | 19.34 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 24 | hr | 304.57 | 57.47 | p-S6 | 10.22 | |
| MK2206 | HCC1954 | 10.0 | uM | 6 | hr | 245.81 | 69.49 | p-S6 | 199.06 | |
| MK2206 | HCC1954 | 10.0 | uM | 24 | hr | 296.67 | 68.02 | p-S6 | 72.61 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 256.84 | 84.85 | p-S6 | 398.99 | |
| Triciribine | HCC1954 | 10.0 | uM | 24 | hr | 217.54 | 89.83 | p-S6 | 389.81 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 273.17 | 84.16 | p-S6 | 19.17 | |
| Dactolisib | HCC1954 | 10.0 | uM | 24 | hr | 271.20 | 74.02 | p-S6 | 8.88 | |
| Gefitinib | MCF 10A | 10.0 | uM | 6 | hr | 179.61 | 131.84 | p-S6 | 327.07 | |
| Gefitinib | MCF 10A | 10.0 | uM | 24 | hr | 187.17 | 27.83 | p-S6 | 16.12 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 539.09 | 143.58 | p-S6 | 324.14 | |
| Torkinib | MCF 10A | 10.0 | uM | 24 | hr | 478.15 | 77.45 | p-S6 | 187.08 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 6 | hr | 202.33 | 118.30 | p-S6 | 6.93 | |
| GSK1059615 | MCF 10A | 10.0 | uM | 24 | hr | 220.59 | 79.70 | p-S6 | 16.06 | |
| MK2206 | MCF 10A | 10.0 | uM | 6 | hr | 361.14 | 138.60 | p-S6 | 492.02 | |
| MK2206 | MCF 10A | 10.0 | uM | 24 | hr | 347.28 | 94.14 | p-S6 | 358.98 | |
| Triciribine | MCF 10A | 10.0 | uM | 6 | hr | 362.33 | 138.87 | p-S6 | 491.28 | |