Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | AU565 | 133.0 | nM | 6 | hr | 327.55 | 58.65 | p-S6 | 12.75 | |
| Torkinib | AU565 | 133.0 | nM | 24 | hr | 365.00 | 60.48 | p-S6 | 10.90 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 274.58 | 58.70 | p-S6 | 34.90 | |
| GSK1059615 | AU565 | 316.0 | nM | 24 | hr | 487.90 | 88.32 | p-S6 | 182.34 | |
| MK2206 | AU565 | 316.0 | nM | 6 | hr | 365.11 | 76.85 | p-S6 | 156.15 | |
| MK2206 | AU565 | 316.0 | nM | 24 | hr | 378.37 | 91.90 | p-S6 | 220.95 | |
| Triciribine | AU565 | 316.0 | nM | 6 | hr | 361.39 | 89.00 | p-S6 | 229.56 | |
| Triciribine | AU565 | 316.0 | nM | 24 | hr | 566.41 | 105.22 | p-S6 | 313.45 | |
| Dactolisib | AU565 | 316.0 | nM | 6 | hr | 344.36 | 67.12 | p-S6 | 16.91 | |
| Dactolisib | AU565 | 316.0 | nM | 24 | hr | 462.54 | 58.51 | p-S6 | 19.15 | |
| Gefitinib | HCC1954 | 316.0 | nM | 6 | hr | 151.41 | 53.15 | p-S6 | 95.96 | |
| Gefitinib | HCC1954 | 316.0 | nM | 24 | hr | 270.48 | 109.80 | p-S6 | 306.96 | |
| Torkinib | HCC1954 | 133.0 | nM | 6 | hr | 159.90 | 25.42 | p-S6 | 10.66 | |
| Torkinib | HCC1954 | 133.0 | nM | 24 | hr | 318.47 | 100.38 | p-S6 | 63.04 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 6 | hr | 446.10 | 86.11 | p-S6 | 34.84 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 24 | hr | 322.84 | 75.37 | p-S6 | 16.64 | |
| MK2206 | HCC1954 | 316.0 | nM | 6 | hr | 250.78 | 80.11 | p-S6 | 248.90 | |
| MK2206 | HCC1954 | 316.0 | nM | 24 | hr | 277.28 | 111.14 | p-S6 | 309.83 | |
| Triciribine | HCC1954 | 316.0 | nM | 6 | hr | 266.36 | 94.38 | p-S6 | 485.30 | |
| Triciribine | HCC1954 | 316.0 | nM | 24 | hr | 247.45 | 107.48 | p-S6 | 333.56 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 231.85 | 69.00 | p-S6 | 9.96 | |
| Dactolisib | HCC1954 | 316.0 | nM | 24 | hr | 280.10 | 66.51 | p-S6 | 11.87 | |
| Gefitinib | MCF 10A | 316.0 | nM | 6 | hr | 223.68 | 160.02 | p-S6 | 420.56 | |
| Gefitinib | MCF 10A | 316.0 | nM | 24 | hr | 262.25 | 189.00 | p-S6 | 404.58 | |
| Torkinib | MCF 10A | 133.0 | nM | 6 | hr | 510.58 | 154.88 | p-S6 | 529.62 | |