HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
GSK1059615	AU565	100.0	nM	24	hr	453.87	115.71	p-4EBP1	166.38
MK2206	AU565	100.0	nM	6	hr	302.08	70.82	p-4EBP1	107.19
MK2206	AU565	100.0	nM	24	hr	354.53	104.31	p-4EBP1	151.28
Triciribine	AU565	100.0	nM	6	hr	214.70	54.97	p-4EBP1	65.17
Triciribine	AU565	100.0	nM	24	hr	498.81	112.95	p-4EBP1	174.19
Dactolisib	AU565	100.0	nM	6	hr	330.98	64.06	p-4EBP1	14.64
Dactolisib	AU565	100.0	nM	24	hr	396.58	64.02	p-4EBP1	26.27
Gefitinib	HCC1954	100.0	nM	6	hr	203.30	78.66	p-4EBP1	85.64
Gefitinib	HCC1954	100.0	nM	24	hr	270.16	123.24	p-4EBP1	131.72
Torkinib	HCC1954	31.6	nM	6	hr	144.70	27.42	p-4EBP1	31.74
Torkinib	HCC1954	31.6	nM	24	hr	262.35	103.57	p-4EBP1	106.07
GSK1059615	HCC1954	100.0	nM	6	hr	229.66	69.48	p-4EBP1	77.07
GSK1059615	HCC1954	100.0	nM	24	hr	247.76	103.78	p-4EBP1	117.81
MK2206	HCC1954	100.0	nM	6	hr	182.03	57.03	p-4EBP1	78.37
MK2206	HCC1954	100.0	nM	24	hr	268.73	123.68	p-4EBP1	145.16
Triciribine	HCC1954	100.0	nM	6	hr	240.14	87.78	p-4EBP1	117.61
Triciribine	HCC1954	100.0	nM	24	hr	292.68	121.22	p-4EBP1	122.83
Dactolisib	HCC1954	100.0	nM	6	hr	201.86	59.83	p-4EBP1	13.31
Dactolisib	HCC1954	100.0	nM	24	hr	270.29	86.15	p-4EBP1	19.38
Gefitinib	MCF 10A	100.0	nM	6	hr	342.18	162.05	p-4EBP1	285.03
Gefitinib	MCF 10A	100.0	nM	24	hr	253.20	163.24	p-4EBP1	174.55
Torkinib	MCF 10A	31.6	nM	6	hr	486.85	159.54	p-4EBP1	207.18
Torkinib	MCF 10A	31.6	nM	24	hr	373.58	173.81	p-4EBP1	118.55
GSK1059615	MCF 10A	100.0	nM	6	hr	320.49	163.19	p-4EBP1	331.19
GSK1059615	MCF 10A	100.0	nM	24	hr	255.40	153.30	p-4EBP1	206.46

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