Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | AU565 | 10.0 | uM | 24 | hr | 426.49 | 72.12 | p-Akt | 20.34 | |
| GSK1059615 | AU565 | 10.0 | uM | 6 | hr | 287.99 | 63.31 | p-Akt | 15.70 | |
| GSK1059615 | AU565 | 10.0 | uM | 24 | hr | 323.29 | 73.24 | p-Akt | 18.11 | |
| MK2206 | AU565 | 10.0 | uM | 6 | hr | 310.26 | 62.42 | p-Akt | 15.88 | |
| MK2206 | AU565 | 10.0 | uM | 24 | hr | 326.13 | 65.38 | p-Akt | 18.65 | |
| Triciribine | AU565 | 10.0 | uM | 6 | hr | 251.46 | 57.85 | p-Akt | 15.41 | |
| Triciribine | AU565 | 10.0 | uM | 24 | hr | 414.15 | 63.54 | p-Akt | 27.27 | |
| Dactolisib | AU565 | 10.0 | uM | 6 | hr | 233.98 | 48.82 | p-Akt | 14.99 | |
| Dactolisib | AU565 | 10.0 | uM | 24 | hr | 466.70 | 65.77 | p-Akt | 21.33 | |
| Gefitinib | HCC1954 | 10.0 | uM | 6 | hr | 158.85 | 51.07 | p-Akt | 22.01 | |
| Gefitinib | HCC1954 | 10.0 | uM | 24 | hr | 230.01 | 66.22 | p-Akt | 41.71 | |
| Torkinib | HCC1954 | 10.0 | uM | 6 | hr | 179.76 | 31.73 | p-Akt | 10.59 | |
| Torkinib | HCC1954 | 10.0 | uM | 24 | hr | 230.32 | 53.62 | p-Akt | 15.31 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 6 | hr | 457.84 | 75.13 | p-Akt | 29.14 | |
| GSK1059615 | HCC1954 | 10.0 | uM | 24 | hr | 329.88 | 59.56 | p-Akt | 19.38 | |
| MK2206 | HCC1954 | 10.0 | uM | 6 | hr | 219.36 | 64.72 | p-Akt | 15.15 | |
| MK2206 | HCC1954 | 10.0 | uM | 24 | hr | 255.20 | 58.01 | p-Akt | 19.08 | |
| Triciribine | HCC1954 | 10.0 | uM | 6 | hr | 271.15 | 84.89 | p-Akt | 24.33 | |
| Triciribine | HCC1954 | 10.0 | uM | 24 | hr | 216.26 | 81.94 | p-Akt | 23.92 | |
| Dactolisib | HCC1954 | 10.0 | uM | 6 | hr | 232.67 | 72.97 | p-Akt | 16.02 | |
| Dactolisib | HCC1954 | 10.0 | uM | 24 | hr | 262.23 | 73.86 | p-Akt | 18.96 | |
| Gefitinib | MCF 10A | 10.0 | uM | 6 | hr | 179.64 | 123.42 | p-Akt | 28.81 | |
| Gefitinib | MCF 10A | 10.0 | uM | 24 | hr | 192.99 | 28.34 | p-Akt | 22.21 | |
| Torkinib | MCF 10A | 10.0 | uM | 6 | hr | 563.34 | 144.82 | p-Akt | 16.90 | |
| Torkinib | MCF 10A | 10.0 | uM | 24 | hr | 425.35 | 75.91 | p-Akt | 12.93 | |