Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Docetaxel | ZR-75-1 | -5.0000 | 0.8419 | -8.3220 | -5.0000 | -7.7256 | 1.4995 | 0.7820 | 0.7820 | 7.9003 |
| Docetaxel | 184B5 | -5.0000 | 0.8431 | -8.6610 | -5.0000 | -8.3663 | 2.1670 | 0.6800 | 0.6800 | 7.7232 |
| Docetaxel | HCC1187 | -5.0000 | 0.9777 | -8.1190 | -8.0930 | -8.6425 | 1.4650 | 0.0712 | 0.0712 | 4.4403 |
| Docetaxel | MCF 10A | -5.0000 | 0.9724 | -8.6485 | -8.4958 | -8.6453 | 1.4580 | 0.1865 | 0.1866 | 4.3758 |
| Docetaxel | MCF 10F | -5.0000 | 0.9663 | -8.6590 | -8.4334 | -8.6146 | 1.7160 | 0.2946 | 0.2946 | 4.9801 |
| Docetaxel | SUM1315MO2 | -5.0000 | 0.9856 | -8.0790 | -7.7519 | -8.3149 | 1.3040 | 0.3126 | 0.3127 | 5.6541 |
| Docetaxel | SUM149PT | -5.0000 | 0.9360 | -8.8090 | -8.6657 | -8.8072 | 2.3100 | 0.2665 | 0.2665 | 4.7876 |
| Docetaxel | SUM159PT | -5.0000 | 0.9753 | -8.7915 | -8.7477 | -8.8094 | 2.1380 | 0.0956 | 0.0956 | 3.6627 |
| Docetaxel | SUM185PE | -5.0000 | 0.9052 | -7.7910 | -5.0000 | -7.7962 | 3.9920 | 0.5991 | 0.5991 | 7.6798 |
| Docetaxel | SUM225CWN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Docetaxel | SUM229PE | -5.0000 | 0.9860 | -7.9790 | -7.6742 | -7.9582 | 1.6750 | 0.3458 | 0.3458 | 5.9634 |
| Docetaxel | SUM52PE | -5.0000 | 0.9765 | -8.6740 | -8.4669 | -8.7954 | 1.5570 | 0.2588 | 0.2588 | 4.8421 |
| Docetaxel | 184A1 | -5.0000 | 0.7750 | -8.2270 | -5.0000 | -6.0351 | 1.3100 | 0.7160 | 0.7160 | 7.8073 |
| Docetaxel | MCF12A | -5.0000 | 0.9298 | -8.6260 | -8.2368 | -8.6178 | 1.3250 | 0.3435 | 0.3436 | 5.1394 |
| Docetaxel | MX1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Docetaxel | T47DKBLUC | -5.0000 | 0.9620 | -7.7980 | -7.3631 | -7.9166 | 1.9650 | 0.4303 | 0.4303 | 6.4961 |
| Docetaxel | 600MPE | -5.0000 | 0.7992 | -7.6820 | -5.0000 | -7.1151 | 2.4180 | 0.7415 | 0.7415 | 8.2414 |
| Docetaxel | HCC2185 | -5.0000 | 0.8601 | -8.4610 | -5.0000 | -8.5299 | 2.8345 | 0.6559 | 0.6559 | 7.0951 |
| Docetaxel | HCC3153 | -5.0000 | 0.9655 | -7.8850 | -7.4961 | -8.0029 | 1.5310 | 0.4040 | 0.4040 | 6.2205 |
| Docetaxel | LY2 | -5.0000 | 0.9638 | -8.2275 | -7.2971 | -8.2340 | 1.5105 | 0.3819 | 0.3819 | 5.9691 |
| Docetaxel | ZR75B | -5.0000 | 0.9309 | -8.2560 | -5.0000 | -7.9688 | 2.3085 | 0.6759 | 0.6759 | 7.3742 |
| Doxorubicin | MCF7 | -6.2596 | 0.9750 | -6.7234 | -6.7235 | -6.9475 | 1.3200 | 0.0000 | 0.1963 | 7.9183 |
| Doxorubicin | SK-BR-3 | -6.2596 | 0.9787 | -6.9014 | -6.8981 | -7.1294 | 1.4280 | 0.0056 | 0.1131 | 7.3714 |
| Doxorubicin | MDA-MB-231 | -6.2596 | 0.9375 | -7.2786 | -7.2786 | -7.4049 | 0.8349 | 0.0000 | 0.1236 | 6.8415 |
| Doxorubicin | AU565 | -6.2596 | 0.9064 | -7.2888 | -7.2496 | -7.4293 | 1.8740 | 0.0680 | 0.0814 | 7.0531 |