Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Lestaurtinib | BT-20 | -4.4776 | 0.9456 | -5.2916 | -5.2914 | -5.5599 | 1.5200 | 0.0000 | 0.0548 | 6.9871 |
| GSK461364 | ZR-75-1 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.9012 |
| Omipalisib | SUM1315MO2 | -4.4776 | 0.9321 | -7.1106 | -6.5244 | -7.9823 | 0.4475 | 0.2268 | 0.2749 | 5.7439 |
| Lestaurtinib | HCC1395 | -4.4776 | 0.9239 | -6.0661 | -6.0657 | -6.9291 | 0.5978 | 0.0000 | 0.1029 | 6.0443 |
| Lestaurtinib | HCC1419 | -4.4776 | 0.8499 | -5.1819 | -5.1820 | -6.2045 | 1.0720 | 0.0000 | 0.1495 | 6.9135 |
| GSK1070916 | MCF7 | -4.4776 | 0.8992 | -4.8142 | -4.8141 | -4.9891 | 2.6155 | 0.0000 | 0.1991 | 8.0618 |
| Lestaurtinib | HCC1806 | -4.4776 | 0.9867 | -6.7396 | -6.7272 | -6.8390 | 1.7540 | 0.0254 | 0.0255 | 5.2897 |
| GSK1070916 | SK-BR-3 | -4.4776 | 0.9215 | -5.1088 | -4.9540 | -5.2937 | 2.7030 | 0.2897 | 0.2978 | 8.0531 |
| Lestaurtinib | HCC1954 | -4.4776 | 0.9359 | -5.2449 | -5.2448 | -5.3917 | 1.9150 | 0.0000 | 0.0328 | 7.0970 |
| Omipalisib | MCF12A | -4.4776 | 0.9856 | -7.9446 | -7.8784 | -8.1272 | 0.6569 | 0.0478 | 0.0528 | 3.8131 |
| GSK461364 | AU565 | -4.4776 | 0.9163 | -7.8996 | -7.8424 | -7.9567 | 3.9990 | 0.1548 | 0.1548 | 4.6399 |
| GSK1070916 | AU565 | -4.4776 | 0.7600 | -5.2504 | -5.2504 | -5.5873 | 0.5535 | 0.0000 | 0.2719 | 6.7505 |
| Lestaurtinib | MB 157 | -4.4776 | 0.9869 | -5.8896 | -5.8833 | -6.0548 | 1.1310 | 0.0086 | 0.0331 | 6.5560 |
| Lestaurtinib | MDA-MB-175-VII | -4.4776 | 0.7465 | -6.0516 | -5.1586 | -6.3133 | 2.4785 | 0.4079 | 0.4115 | 7.0386 |
| Lestaurtinib | MDA-MB-361 | -4.4776 | 0.9520 | -5.7011 | -5.7009 | -6.3335 | 1.1589 | 0.0000 | 0.0548 | 6.8121 |
| GSK1070916 | BT-474 | -4.4776 | 0.9390 | -4.8892 | -4.8892 | -5.1976 | 1.5185 | 0.0000 | 0.1965 | 7.9844 |
| Lestaurtinib | MDA-MB-453 | -4.4776 | 0.9758 | -5.8596 | -5.8463 | -6.2015 | 1.1420 | 0.0175 | 0.0428 | 6.6264 |
| Lestaurtinib | CAMA-1 | -4.4776 | 0.8685 | -5.3860 | -5.3862 | -5.9355 | 1.2339 | 0.0000 | 0.0977 | 6.8083 |
| GSK461364 | 184B5 | -4.4776 | 0.7303 | -5.5881 | -5.5882 | -6.3658 | 0.4307 | 0.0000 | 0.2496 | 6.7499 |
| Lestaurtinib | ZR-75-1 | -4.4776 | 0.8071 | -4.9951 | -4.9951 | -5.8634 | 0.5333 | 0.0000 | 0.3460 | 7.1442 |
| Lestaurtinib | HCC2185 | -4.4776 | 0.9600 | -5.2660 | -5.2455 | -5.5452 | 2.7830 | 0.0650 | 0.0764 | 7.4902 |
| GSK1070916 | CAMA-1 | -4.4776 | 0.9256 | -4.6946 | -4.6945 | -5.0755 | 1.3570 | 0.0000 | 0.3367 | 7.9134 |
| Lestaurtinib | HCC1187 | -4.4776 | 0.8869 | -5.6306 | -5.6305 | -6.0003 | 0.6822 | 0.0000 | 0.1405 | 6.9718 |
| GSK923295 | MCF 10A | -4.4776 | 0.9412 | -7.4031 | -7.1898 | -7.3207 | 3.0580 | 0.3669 | 0.3669 | 5.9720 |
| GSK923295 | HCC1187 | -4.4776 | 0.9843 | -7.4796 | -7.4551 | -7.6694 | 3.9940 | 0.0876 | 0.0876 | 4.5239 |