Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Fascaplysin | SUM1315MO2 | -4.4776 | 0.9611 | -6.1336 | -6.1327 | -6.3906 | 2.7410 | 0.0059 | 0.0081 | 6.2950 |
| Fascaplysin | SUM149PT | -4.4776 | 0.9776 | -6.3746 | -6.3720 | -6.4522 | 2.5280 | 0.0082 | 0.0082 | 5.8486 |
| Omipalisib | BT-20 | -4.4776 | 0.9798 | -7.1356 | -7.1020 | -7.8044 | 0.7553 | 0.1163 | 0.1218 | 4.8945 |
| Omipalisib | BT-474 | -4.4776 | 0.9827 | -7.6646 | -7.5992 | -8.3285 | 0.7338 | 0.0520 | 0.0564 | 4.2655 |
| Fascaplysin | SUM52PE | -4.4776 | 0.9805 | -6.4616 | -6.4614 | -6.7280 | 1.5690 | 0.0000 | 0.0008 | 5.4847 |
| Fascaplysin | 184A1 | -4.4776 | 0.9829 | -6.3051 | -6.3045 | -6.4382 | 2.4270 | 0.0007 | 0.0007 | 5.9730 |
| Fascaplysin | T47DKBLUC | -4.4776 | 0.9903 | -7.1796 | -7.1786 | -7.3774 | 2.5360 | 0.0036 | 0.0036 | 4.5486 |
| Fascaplysin | 600MPE | -4.4776 | 0.9843 | -6.4026 | -6.4010 | -6.5333 | 3.9995 | 0.0053 | 0.0053 | 5.6846 |
| Fascaplysin | HCC3153 | -4.4776 | 0.9915 | -6.3846 | -6.3845 | -6.6083 | 2.0430 | 0.0007 | 0.0010 | 5.6496 |
| Fascaplysin | ZR75B | -4.4776 | 0.9810 | -6.3476 | -6.3463 | -6.4454 | 2.7840 | 0.0030 | 0.0030 | 5.7017 |
| Lestaurtinib | BT-474 | -4.4776 | 0.9214 | -5.6966 | -5.6966 | -6.6970 | 0.7403 | 0.0000 | 0.1226 | 6.4193 |
| Lestaurtinib | HCC1954 | -4.4776 | 0.9359 | -5.2449 | -5.2448 | -5.3917 | 1.9150 | 0.0000 | 0.0328 | 7.0970 |
| Omipalisib | HCC1395 | -4.4776 | 0.9674 | -7.0311 | -6.6125 | -7.3086 | 0.9230 | 0.2903 | 0.2936 | 6.1517 |
| Omipalisib | HCC1419 | -4.4776 | 0.9393 | -7.8176 | -7.3177 | -8.7550 | 0.7216 | 0.2822 | 0.2850 | 5.2439 |
| GSK461364 | BT-549 | -4.4776 | 0.9641 | -7.4546 | -7.3658 | -7.4956 | 1.5300 | 0.1350 | 0.1350 | 5.0110 |
| Omipalisib | HCC1806 | -4.4776 | 0.9844 | -7.2646 | -7.1920 | -7.5727 | 0.6333 | 0.0504 | 0.0665 | 4.7285 |
| Omipalisib | HCC1954 | -4.4776 | 0.9507 | -7.8256 | -7.7807 | -8.1463 | 1.1974 | 0.0450 | 0.0466 | 3.8101 |
| Omipalisib | HCC202 | -4.4776 | 0.9925 | -8.0786 | -8.0068 | -8.9423 | 0.9984 | 0.0758 | 0.0760 | 3.7918 |
| GSK461364 | HCC1937 | -4.4776 | 0.9499 | -6.4746 | -6.3569 | -7.4841 | 0.4122 | 0.0508 | 0.1980 | 5.7820 |
| Omipalisib | MDA-MB-134-VI | -4.4776 | 0.9885 | -7.2176 | -7.2177 | -7.9713 | 0.7442 | 0.0000 | 0.0092 | 4.4619 |
| Omipalisib | MDA-MB-175-VII | -4.4776 | 0.9651 | -7.4526 | -7.2379 | -8.2980 | 0.6747 | 0.1421 | 0.1505 | 4.9106 |
| Omipalisib | MDA-MB-361 | -4.4776 | 0.9850 | -7.9296 | -7.9292 | -8.7448 | 0.8961 | 0.0000 | 0.0012 | 3.5825 |
| Omipalisib | MDA-MB-468 | -4.4776 | 0.9771 | -7.1516 | -7.0505 | -7.5021 | 0.5801 | 0.0633 | 0.0889 | 4.9370 |
| GSK923295 | HCC1143 | -4.4776 | 0.8172 | -7.1321 | -5.3503 | -7.1299 | 1.0993 | 0.5082 | 0.5099 | 7.0065 |
| GSK923295 | CAMA-1 | -4.4776 | 0.9171 | -7.3906 | -4.4776 | -7.4011 | 3.9990 | 0.5231 | 0.5231 | 6.7121 |