Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1070916 | MDA-MB-231 | -4.4776 | 0.8912 | -5.4548 | -5.4547 | -5.5379 | 0.9323 | 0.0000 | 0.1121 | 6.9162 |
| GSK461364 | AU565 | -4.4776 | 0.9163 | -7.8996 | -7.8424 | -7.9567 | 3.9990 | 0.1548 | 0.1548 | 4.6399 |
| Omipalisib | AU565 | -4.4776 | 0.9675 | -8.1726 | -7.7602 | -8.1358 | 0.7102 | 0.2454 | 0.2472 | 4.7024 |
| GSK1070916 | SK-BR-3 | -4.4776 | 0.9215 | -5.1088 | -4.9540 | -5.2937 | 2.7030 | 0.2897 | 0.2978 | 8.0531 |
| GSK1070916 | MCF7 | -4.4776 | 0.8992 | -4.8142 | -4.8141 | -4.9891 | 2.6155 | 0.0000 | 0.1991 | 8.0618 |
| GSK461364 | ZR-75-1 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.9012 |
| Omipalisib | BT-20 | -4.4776 | 0.9798 | -7.1356 | -7.1020 | -7.8044 | 0.7553 | 0.1163 | 0.1218 | 4.8945 |
| GSK461364 | HCC1937 | -4.4776 | 0.9499 | -6.4746 | -6.3569 | -7.4841 | 0.4122 | 0.0508 | 0.1980 | 5.7820 |
| GSK461364 | BT-549 | -4.4776 | 0.9641 | -7.4546 | -7.3658 | -7.4956 | 1.5300 | 0.1350 | 0.1350 | 5.0110 |
| Fascaplysin | MCF7 | -4.4776 | 0.9785 | -6.5106 | -6.5102 | -6.6917 | 1.9035 | 0.0000 | 0.0002 | 5.5745 |
| Fascaplysin | SK-BR-3 | -4.4776 | 0.9777 | -6.4881 | -6.4810 | -6.6994 | 1.1708 | 0.0110 | 0.0184 | 5.5640 |
| GSK461364 | HCC1806 | -4.4776 | 0.9549 | -7.9236 | -7.8853 | -7.9576 | 4.0000 | 0.1486 | 0.1486 | 4.4396 |
| GSK461364 | UACC-893 | -4.4776 | 0.7393 | -8.2951 | -8.0674 | -8.3748 | 3.9960 | 0.4309 | 0.4309 | 5.6830 |
| Fascaplysin | BT-483 | -4.4776 | 0.9919 | -7.0166 | -7.0138 | -7.2225 | 3.7420 | 0.0125 | 0.0125 | 4.8829 |
| Fascaplysin | BT-549 | -4.4776 | 0.9726 | -6.3291 | -6.3287 | -6.3581 | 3.2605 | 0.0013 | 0.0014 | 6.1230 |
| Omipalisib | BT-474 | -4.4776 | 0.9827 | -7.6646 | -7.5992 | -8.3285 | 0.7338 | 0.0520 | 0.0564 | 4.2655 |
| Fascaplysin | HCC1395 | -4.4776 | 0.9894 | -6.3281 | -6.3267 | -6.5158 | 2.4265 | 0.0037 | 0.0037 | 5.8352 |
| Fascaplysin | HCC1428 | -4.4776 | 0.9933 | -7.2466 | -7.2446 | -7.4391 | 2.6515 | 0.0054 | 0.0054 | 4.4905 |
| Fascaplysin | HCC1569 | -4.4776 | 0.9831 | -6.2996 | -6.2991 | -6.3953 | 2.3550 | 0.0024 | 0.0024 | 5.8015 |
| Omipalisib | HCC70 | -4.4776 | 0.9751 | -7.5826 | -7.5358 | -8.1178 | 0.8673 | 0.0444 | 0.0464 | 4.2358 |
| Omipalisib | ZR75B | -4.4776 | 0.9866 | -8.1786 | -7.9344 | -8.3356 | 0.8804 | 0.1953 | 0.1957 | 4.3371 |
| Fascaplysin | HCC38 | -4.4776 | 0.9742 | -6.4461 | -6.4462 | -6.5732 | 2.1780 | 0.0000 | 0.0001 | 5.3893 |
| Fascaplysin | HCC70 | -4.4776 | 0.9766 | -6.5836 | -6.5841 | -6.9057 | 1.5250 | 0.0000 | 0.0006 | 5.2074 |
| Fascaplysin | MCF 10A | -4.4776 | 0.9668 | -6.4206 | -6.4210 | -6.4700 | 2.9050 | 0.0001 | 0.0002 | 5.8112 |
| Fascaplysin | HCC1187 | -4.4776 | 0.9758 | -7.7196 | -7.7192 | -7.9829 | 2.0550 | 0.0021 | 0.0021 | 4.1023 |