Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1070916 | HCC3153 | -4.4776 | 0.9272 | -4.5125 | -4.6484 | -4.9835 | 0.8079 | 0.0000 | 0.4785 | 7.9589 |
| Gefitinib | ZR-75-1 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.8826 |
| Gefitinib | T47D | -4.4776 | 0.8564 | -4.5556 | -4.5556 | -4.8564 | 1.0790 | 0.0000 | 0.4517 | 7.9218 |
| Gefitinib | 184B5 | -4.4776 | 0.9725 | -7.3466 | -6.6212 | -7.4590 | 0.9009 | 0.3889 | 0.3905 | 6.2609 |
| GSK461364 | SUM149PT | -4.4776 | 0.9733 | -8.0241 | -7.9672 | -8.0354 | 2.7685 | 0.1432 | 0.1432 | 4.1533 |
| Taxol | HCC1954 | -4.4776 | 0.9763 | -8.0066 | -7.9811 | -8.1129 | 2.9265 | 0.0778 | 0.0778 | 3.9876 |
| GSK1070916 | MCF12A | -4.4776 | 0.8094 | -5.0180 | -5.0180 | -5.2827 | 1.0610 | 0.0000 | 0.2108 | 7.3701 |
| GSK1070916 | 184A1 | -4.4776 | 0.9369 | -5.1921 | -4.8387 | -6.0739 | 0.6165 | 0.1938 | 0.4077 | 7.6066 |
| Gefitinib | MDA-MB-436 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 9.0406 |
| GSK1070916 | SUM52PE | -4.4776 | 0.9679 | -6.5456 | -6.3714 | -6.8589 | 0.8088 | 0.1362 | 0.1547 | 6.1498 |
| GSK1070916 | SUM229PE | -4.4776 | 0.9250 | -5.8586 | -5.8590 | -6.2571 | 0.5466 | 0.0000 | 0.1495 | 6.3665 |
| GSK461364 | HCC38 | -4.4776 | 0.9483 | -7.5136 | -7.4139 | -7.5675 | 3.7870 | 0.2893 | 0.2893 | 5.5548 |
| GSK1070916 | 600MPE | -4.4776 | 0.9645 | -4.9183 | -4.9070 | -5.0505 | 4.0000 | 0.0475 | 0.0640 | 8.2035 |
| GSK1070916 | HCC2185 | -4.4776 | 0.8250 | -4.7029 | -4.7028 | -6.4154 | 0.4977 | 0.0000 | 0.4321 | 7.5269 |
| Gefitinib | MDA-MB-453 | -4.4776 | 0.9017 | -5.0927 | -5.0358 | -5.1652 | 3.9970 | 0.1820 | 0.1849 | 8.3260 |
| GSK1070916 | LY2 | -4.4776 | 0.9589 | -4.9577 | -4.9576 | -4.9710 | 2.6450 | 0.0000 | 0.0510 | 7.6939 |
| GSK1070916 | ZR75B | -4.4776 | 0.8084 | -4.6326 | -4.6513 | -5.7720 | 0.3741 | 0.0000 | 0.4696 | 7.4366 |
| Gefitinib | UACC-893 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.3372 |
| Gefitinib | MDA-MB-468 | -4.4776 | NaN | NaN | NaN | -4.5220 | NaN | NaN | NaN | 8.9041 |
| GSK1070916 | SUM185PE | -4.4776 | 0.9052 | -5.4942 | -5.4944 | -5.9594 | 1.3090 | 0.0000 | 0.0450 | 7.4398 |
| Gefitinib | HCC1187 | -4.4776 | 0.7375 | -4.3209 | -4.4776 | -4.5207 | 2.1830 | 0.0069 | 0.6893 | 8.9050 |
| GSK1070916 | SUM159PT | -4.4776 | 0.9045 | -5.7426 | -5.7426 | -5.6673 | 0.5924 | 0.0000 | 0.1507 | 6.6500 |
| GSK1070916 | SUM149PT | -4.4776 | 0.9459 | -5.4509 | -5.4508 | -5.5356 | 1.0515 | 0.0000 | 0.1207 | 6.9589 |
| GSK461364 | SUM1315MO2 | -4.4776 | 0.9468 | -7.5016 | -7.3301 | -7.6637 | 2.4270 | 0.3088 | 0.3088 | 5.6429 |
| Taxol | HCC1806 | -4.4776 | 0.9897 | -8.0876 | -8.0685 | -8.1579 | 2.7400 | 0.0655 | 0.0655 | 3.6186 |