Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK461364 | MCF7 | -4.4776 | 0.8031 | -6.3506 | -4.6631 | -6.4936 | 3.1375 | 0.3164 | 0.3789 | 7.0589 |
| GSK1070916 | 600MPE | -4.4776 | 0.9645 | -4.9183 | -4.9070 | -5.0505 | 4.0000 | 0.0475 | 0.0640 | 8.2035 |
| Gefitinib | LY2 | -4.4776 | 0.9408 | -4.4519 | -4.4776 | -4.6343 | 1.3760 | 0.0003 | 0.5205 | 8.3711 |
| Taxol | AU565 | -4.4776 | 0.9817 | -8.0346 | -8.0127 | -8.1165 | 3.4830 | 0.0920 | 0.0920 | 3.9264 |
| Gefitinib | BT-474 | -4.4776 | 0.8631 | -5.3558 | -5.3557 | -6.1316 | 1.2500 | 0.0000 | 0.0487 | 6.8511 |
| Gefitinib | BT-483 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.6514 |
| Gefitinib | SUM149PT | -4.4776 | 0.9252 | -5.3205 | -5.3206 | -5.5832 | 0.5041 | 0.0000 | 0.2732 | 7.0793 |
| Gefitinib | AU565 | -4.4776 | 0.9681 | -5.6452 | -5.5800 | -5.9334 | 0.9489 | 0.0674 | 0.1471 | 6.9371 |
| GSK461364 | SUM149PT | -4.4776 | 0.9733 | -8.0241 | -7.9672 | -8.0354 | 2.7685 | 0.1432 | 0.1432 | 4.1533 |
| Gefitinib | BT-549 | -4.4776 | 0.8774 | -4.7649 | -4.7649 | -4.8099 | 1.0490 | 0.0000 | 0.3521 | 7.9303 |
| Gefitinib | SUM159PT | -4.4776 | 0.8358 | -5.0443 | -5.0419 | -5.0297 | 2.1815 | 0.0000 | 0.0836 | 7.6696 |
| Gefitinib | MCF7 | -4.4776 | 0.8208 | -4.4459 | -4.4776 | -4.5825 | 1.0390 | 0.0000 | 0.5190 | 8.1555 |
| GSK461364 | HCC38 | -4.4776 | 0.9483 | -7.5136 | -7.4139 | -7.5675 | 3.7870 | 0.2893 | 0.2893 | 5.5548 |
| Gefitinib | SK-BR-3 | -4.4776 | 0.8563 | -5.1609 | -5.1281 | -5.5758 | 0.9494 | 0.0429 | 0.2585 | 7.2336 |
| Gefitinib | MDA-MB-231 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.9556 |
| GSK461364 | SUM1315MO2 | -4.4776 | 0.9468 | -7.5016 | -7.3301 | -7.6637 | 2.4270 | 0.3088 | 0.3088 | 5.6429 |
| Gefitinib | CAMA-1 | -4.4776 | 0.7673 | -4.6501 | -4.4776 | -4.6796 | 3.9950 | 0.3020 | 0.6232 | 8.7188 |
| Gefitinib | SUM1315MO2 | -4.4776 | 0.8859 | -4.8028 | -4.7982 | -5.8397 | 0.6483 | 0.1433 | 0.4633 | 7.7921 |
| Gefitinib | SUM185PE | -4.4776 | 0.9604 | -4.9626 | -4.8841 | -5.0834 | 3.9930 | 0.2568 | 0.2653 | 8.4896 |
| Taxol | 184A1 | -4.4776 | 0.8586 | -7.7586 | -4.4776 | -7.1300 | 1.5600 | 0.6613 | 0.6613 | 7.5136 |
| Gefitinib | HCC1143 | -4.4776 | 0.7888 | -4.8484 | -4.5649 | -5.0588 | 1.0312 | 0.2441 | 0.4962 | 8.4272 |
| Taxol | MCF12A | -4.4776 | 0.9575 | -7.9916 | -7.8720 | -7.9736 | 3.9900 | 0.3105 | 0.3105 | 5.1298 |
| GSK1070916 | 184B5 | -4.4776 | 0.9613 | -5.3762 | -5.3761 | -6.1627 | 0.5692 | 0.0000 | 0.2357 | 7.0319 |
| GSK1070916 | ZR-75-1 | -4.4776 | 0.8070 | -4.4399 | -4.4776 | -4.9738 | 2.1600 | 0.3143 | 0.6295 | 8.0879 |
| Gefitinib | MCF 10A | -4.4776 | 0.9631 | -6.1856 | -6.1532 | -6.2264 | 2.7300 | 0.0927 | 0.0927 | 6.4305 |